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489652 MC1R

489652

MC1R

melanocortin 1 receptor

protein-coding

Canis lupus familiaris

基因描述

Type Description
Definition melanocortin 1 receptor

研究结论

Date Results Publications
2018-09-08 10:46:00 Huskies that carry two copies of MC1R loss-of-function alleles have a white coat color. A single nucleotide variant within the MITF binding site of the canine MC1R promoter leads to the cream phenotype in Australian Cattle Dogs. 29932470
2018-05-12 10:50:00 Compared with the wild-type MC1R genotype, nociceptive sensitivity to mechanical force in dogs with a single variant R306ter allele may be greater. However, in contrast to the reported association between homozygous MC1R variants (associated with red hair color) and nociception in humans, we found no evidence of a similar relationship in dogs with the homozygous variant genotype. 28214221
2013-08-10 10:36:00 high heterozygosity and allelic differences at the MC1R locus may explain both the mixed color coat, of yellow and black, and the difference in coat colors in both Kunming dog populations 23424634
2013-06-22 11:31:00 The results of this study suggest that differential expression of ASIP determine pigment-type switching in a MC1R and K allele-dependent manner in dogs. 22524303
2011-12-03 11:23:00 2 key mutations in the MC1R gene and the CBD103 gene are associated with the phenotypic discriminations among brindle, red/sesame, and white coats. 21321476

名称对应

Type IDs
Synonymous MC1-R, MSH-R
Gene
UniProtKB-ID: M1R1N5_CANLF
UniprotKB: M1R1N5
UniParc: UPI00004A475B
EMBL: KC332525, KC332520, KC332524, KC332503, KC332580, KC332511, KC332547, KC332519, KC332505, KC332650, KC332510, KC332539, KC332555, KC332557, KC332523, KC332673, KC332577, KC332533, KC332591, KC332597, KC332550, KC332645, KC332674, KC332521, KC332588, KC332565, KC332491, KC332595, KC332589, KC332623, KC332644, KC332583, KC332572, KC332598, KC332603, KC332675, KC332553, KC332493, KC332671, KC332685, KC332545, KC332498, KC332540, KC332515, KC332496, KC332612, KC332495, KC332581, KC332593, KC332563, KC332537, KC332629, KC332544, KC332561, KC332647, KC332509, KC332663, KC332497, KC332619, KC332627, KC332492, KC332609, KC332527, KC332559, KC332611, KC332679, KC332501, KC332531, KC332579, KJ363163, KC332651, KC332587, KC332551, KC332499, KC332529, KC332516, KC332621, KC332549, KC332585, KC332649, KC332664, KC332571, KC332622, KC332541, KC332639, KC332528, KC332535, KC332680, KC332567, KC332543, KC332643, KC332536, KC332582
KO: cfa:489652
Nucleutide sequences
EMBL-CDS: AGG12082.1, AGG12175.1, AGG12088.1, AGG12221.1, AGG12116.1, AGG12142.1, AGG12132.1, AGG12092.1, AGG12174.1, AGG12222.1, AGG12160.1, AGG12251.1, AGG12172.1, AGG12122.1, AGG12117.1, AGG12159.1, AGG12186.1, AGG12072.1, AGG12164.1, AGG12206.1, AGG12200.1, AGG12118.1, AGG12216.1, AGG12149.1, AGG12250.1, AGG12189.1, AGG12102.1, AGG12256.1, AGG12128.1, AGG12140.1, AGG12110.1, AGG12068.1, AGG12114.1, AGG12124.1, AGG12126.1, AGG12113.1, AGG12199.1, AGG12073.1, AGG12198.1, AGG12220.1, AGG12078.1, AGG12241.1, AGG12156.1, AGG12070.1, AGG12228.1, AGG12138.1, AGG12076.1, AGG12224.1, AGG12108.1, AGG12087.1, AGG12252.1, AGG12097.1, AGG12127.1, AGG12080.1, AGG12180.1, AGG12262.1, AGG12170.1, AGG12121.1, AGG12120.1, AGG12130.1, AGG12101.1, AGG12093.1, AGG12166.1, AGG12154.1, AGG12162.1, AGG12204.1, AGG12100.1, AGG12074.1, AGG12075.1, AGG12098.1, AGG12148.1, AGG12106.1, AGG12227.1, AGG12257.1, AGG12240.1, AGG12096.1, AGG12165.1, AGG12086.1, AGG12196.1, AGG12158.1, AGG12168.1, AGG12136.1, AGG12188.1, AGG12226.1, AHW68474.1, AGG12248.1, AGG12105.1, AGG12134.1, AGG12112.1, AGG12144.1, AGG12104.1, AGG12157.1, AGG12069.1
Protein sequencees
RefSeq: NP_001014304.2
Others
UniRef100: UniRef100_M1R1N5
UniRef90: UniRef90_Q6A155
UniRef50: UniRef50_Q01726
UniGene: Cfa.23471

全选

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研究热度

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