| Type | Description |
|---|---|
| Definition | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-09 11:17:00 | Data show that the nucleotide sequence from -280 to -135 position is an ATP2A3 epigenetic regulatory CpG region. SERCA3 mRNA expression is decreased during gastric and colorectal carcinoma development and tumors with high SERCA3 expression are associated with increased overall survival. These results suggest an essential role for SERCA3 in the regulation of cellular identity and growth, through cellular Ca2+ management. | 30657210 |
| 2019-08-17 12:32:00 | This study demonstrates that ATP2A3 might be one of the potential targets for salinomycin, which can inhibit Ca(2+) release and trigger ER stress to exert anti-cancer effects. | 31023247 |
| 2017-09-02 11:46:00 | Sp1, Sp3, and Klf-4 transcription factors bind to ATP2A3 proximal promoter elements and regulate basal gene expression. The study showed that these factors participated in the increase of ATP2A3 expression during cancer cell differentiation. | 27433831 |
| 2017-07-15 12:29:00 | Together, these data provide evidence for the interaction of Bcl-2 with SERCA3b in vitro and in cell culture, and for Bcl-2-dependent conformational and functional changes of SERCA3b. | 27639965 |
| 2017-06-10 10:13:00 | ATP2A3 methylation was not altered between patients with type 2 diabetes and healthy men. Moreover, a glucose challenge did not alter ATP2A3 methylation. | 28011458 |
| Type | IDs |
|---|---|
| Synonymous | SERCA3 |
| Gene |
UniProtKB-ID:
AT2A3_HUMAN,
A8K9K1_HUMAN
UniprotKB:
Q93084,
A8K9K1
UniParc:
UPI00001261E5,
UPI00015DAA2F,
UPI00024B9D11,
UPI0000161585,
UPI0000001C44,
UPI000002A430,
UPI000002A42F,
UPI0000161584
EMBL:
Y15726,
Y15730,
S68239,
AF458228,
Z69881,
Y15729,
Z69880,
AF068221,
AC005940,
Y15728,
BC035729,
AY460339,
Y15724,
Y15737,
Y15725,
AF458229,
CH471108,
Y15738,
AF068220,
AK292716,
Y15727
Ensembl:
ENSG00000074370
KO:
hsa:489
|
| Nucleutide sequences |
EMBL-CDS:
AAH35729.1,
CAA93736.1,
AAR15415.1,
AAL78968.1,
EAW90469.1,
AAC24525.1,
AAL78967.1,
CAA93737.1,
AAC24526.1,
CAA75747.1,
EAW90468.1,
AAB29700.1,
CAA75748.1,
EAW90463.1,
CAA75739.1,
BAF85405.1
Ensembl_TRS:
ENST00000397043,
ENST00000397035,
ENST00000397041,
ENST00000359983,
ENST00000309890,
ENST00000352011
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000380229,
ENSP00000380234,
ENSP00000380236,
ENSP00000312577,
ENSP00000301387,
ENSP00000353072
RefSeq:
XP_011522187.1,
XP_011522190.1,
XP_011522186.1,
XP_011522184.1,
NP_777615.1,
NP_777613.1,
NP_777616.1,
XP_011522191.1,
XP_016880181.1,
XP_011522183.1,
NP_777614.1,
XP_011522194.1,
NP_777617.1,
XP_016880182.1,
NP_777618.1,
NP_005164.2
|
| Others |
UniRef100:
UniRef100_Q93084,
UniRef100_A8K9K1
UniRef90:
UniRef90_Q93084
UniRef50:
UniRef50_Q93084
UniGene:
Hs.513870
CCDS:
CCDS11042.1,
CCDS45580.1,
CCDS11041.1,
CCDS42234.1,
CCDS45579.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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