| Type | Description |
|---|---|
| Definition | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 10:59:00 | We assessed the genomic landscape of canine hemangiosarcoma via whole-exome sequencing (47 golden retriever hemangiosarcomas) and RNA sequencing (74 hemangiosarcomas from multiple breeds). Somatic coding mutations occurred most frequently in the tumor suppressor TP53 (59.6% of cases) as well as two genes in the PI3K pathway: the oncogene PIK3CA (29.8%) and its regulatory subunit PIK3R1 (8.5%). | 31570656 |
| 2012-09-01 10:41:00 | IGF-1 and PDGF-bb are potent inhibitors of IL-1beta-mediated activation of NF-kappaB and apoptosis in chondrocytes, may be mediated in part through suppression of Src/PI-3K/AKT pathway. | 22194879 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
A0A5F4C2B1_CANLF
UniprotKB:
A0A5F4C2B1
UniParc:
UPI000002F88B
EMBL:
AAEX03017250,
AAEX03017249
Ensembl:
ENSCAFG00000011212
|
| Nucleutide sequences |
Ensembl_TRS:
ENSCAFT00000080543
|
| Protein sequencees |
Ensembl_PRO:
ENSCAFP00000048355
RefSeq:
XP_545208.2,
XP_022270060.1
|
| Others |
UniRef100:
UniRef100_P32871
UniRef90:
UniRef90_P42336
UniRef50:
UniRef50_P42336
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
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