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4832 NME3

4832

NME3

NME/NM23 nucleoside diphosphate kinase 3

protein-coding

Homo sapiens

基因描述

Type Description
Definition NME/NM23 nucleoside diphosphate kinase 3

研究结论

Date Results Publications
2021-02-20 13:35:00 NME3 Regulates Mitochondria to Reduce Genome Instability. 32708927
2019-05-04 12:42:00 Proinflammatory signaling mediated by innate immunity engagement of flagellin-activated TLR5 in tumor cells results in antitumor effects through NME3 kinase, a positive downstream regulator of flagellin-mediated NFkappaB signaling, enhancing survival for several human cancers. 29523766
2019-03-16 10:16:00 Given the critical role of mitochondrial dynamics and energy requirements in neuronal development, the homozygous mutation in NME3 is linked to a fatal mitochondrial neurodegenerative disorder. 30587587
2019-03-09 12:51:00 The ciliopathy-typical manifestations of NME3 depletion in two vertebrate in vivo models, the biochemical association of NME3 with validated NPHPs, and its localization to the basal body reveal a role for NME3 in ciliary function. We conclude that mutations in the NME3 gene may aggravate the ciliopathy phenotypes observed in humans. 30111592
2017-06-10 13:07:00 Thus Tip60 interacts with RNR and NME3 to provide site-specific synthesis of dNTP for facilitating DNA repair in serum-deprived cells which contain low levels of dNTPs. 26945015

名称对应

Type IDs
Synonymous DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2
Gene
UniProtKB-ID: NDK3_HUMAN
UniprotKB: Q13232
UniParc: UPI000012FE88
EMBL: BC000250, AE006639, U29656
Ensembl: ENSG00000103024
KO: hsa:4832
Nucleutide sequences
EMBL-CDS: AAH00250.1, AAA85097.1, AAK61291.1
Ensembl_TRS: ENST00000219302
Protein sequencees
Ensembl_PRO: ENSP00000219302
RefSeq: NP_002504.2, XP_005255389.1, XP_011520806.1, XP_011520805.1
Others
UniRef100: UniRef100_Q13232
UniRef90: UniRef90_Q13232
UniRef50: UniRef50_Q13232
UniGene: Hs.514065
CCDS: CCDS10443.1

全选

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