| Type | Description |
|---|---|
| Definition | ATP citrate lyase |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:27:00 | In Steatotic Cells, ATP-Citrate Lyase mRNA Is Efficiently Translated through a Cap-Independent Mechanism, Contributing to the Stimulation of Lipogenesis. | 32054087 |
| 2020-05-02 11:18:00 | low ACLY expression is associated with favorable overall survival in acute myeloid leukemia patients. | 31077215 |
| 2020-05-02 10:49:00 | This study reports cryo-EM structures of human ACLY, alone or bound to substrates or products. ACLY forms a homotetramer with a rigid citrate synthase homology (CSH) module, flanked by four flexible acetyl-CoA synthetase homology (ASH) domains; CoA is bound at the CSH-ASH interface in mutually exclusive productive or unproductive conformations. | 31873304 |
| 2019-12-21 12:06:00 | structure of the full-length human ACLY homo-tetramer in complex with an inhibitor (NDI-091143) by cryo-electron microscopy, which reveals an unexpected mechanism of inhibition | 30944472 |
| 2019-12-21 12:06:00 | high-resolution crystal structures of bacterial, archaeal and human ACLY, and use distinct substrate-bound states to link the conformational plasticity of ACLY to its multistep catalytic itinerary | 30944476 |
| Type | IDs |
|---|---|
| Synonymous | ACL, ATPCL, CLATP |
| Gene |
UniProtKB-ID:
ACLY_HUMAN,
Q4LE36_HUMAN,
A0A024R1Y2_HUMAN,
A0A024R1T9_HUMAN
UniprotKB:
P53396,
Q4LE36,
A0A024R1Y2,
A0A024R1T9
UniParc:
UPI000054C931,
UPI000013CDF3,
UPI0000225CC0,
UPI00017A88FD
EMBL:
AK295675,
CH471152,
AC125257,
AC091172,
AB210035,
U18197,
BC006195,
AK304802,
X64330
Ensembl:
ENSG00000131473
KO:
hsa:47
|
| Nucleutide sequences |
EMBL-CDS:
BAG58532.1,
AAH06195.1,
AAB60340.1,
BAG65552.1,
CAA45614.1,
BAE06117.1,
EAW60778.1,
EAW60777.1,
EAW60781.1,
EAW60779.1
Gene_ORFName:
hCG_19718,
hCG_19718
Ensembl_TRS:
ENST00000352035,
ENST00000393896,
ENST00000590151,
ENST00000353196,
ENST00000537919
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000466259,
ENSP00000445349,
ENSP00000377474,
ENSP00000253792,
ENSP00000345398
RefSeq:
XP_016880177.1,
XP_005257452.1,
NP_942127.1,
NP_001087.2,
NP_001290203.1,
NP_001290204.1
|
| Others |
UniRef100:
UniRef100_A0A024R1Y2,
UniRef100_P53396
UniRef90:
UniRef90_P53396
UniRef50:
UniRef50_P53396
UniGene:
Hs.387567
CCDS:
CCDS11413.1,
CCDS11412.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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