| Type | Description |
|---|---|
| Definition | myelin transcription factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:17:00 | MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex. | 32251364 |
| 2019-11-02 12:08:00 | PICOT knock-down in Jurkat T cells resulted in a reduced histone H3 lysine 27 trimethylation (H3K27me3) at the PRC2 target gene, myelin transcription factor 1 (MYT1), suggesting that PICOT binding to EED alters PRC2-regulated transcriptional repression, and potentially contributes to the epigenetic regulation of chromatin silencing and remodeling. | 30595380 |
| 2019-06-01 11:03:00 | Here we demonstrate that re-expression of Myt1 or Myt1l in glioblastoma (GBM) cell lines slows proliferation, that expression of both is lower in more aggressive sub-types of glioma, and that reduced expression correlates with poor prognosis in both GBM and low grade glioma, and our data suggest that Myt1 and Myt1l directly repress expression of YAP1, a protein which promotes proliferation and GBM growth. | 30312684 |
| 2019-03-02 12:08:00 | wide analyses of the effects of Myt1 and Myt1l expression in a glioblastoma cell line suggest that the two proteins have largely similar effects on endogenous gene expression. Transcriptional repression is likely mediated by binding to DNA via the known consensus site, whereas this site is not associated with the transcriptional start sites of genes with higher expression in the presence of Myt1 or Myt1l. | 29291346 |
| 2017-12-09 13:34:00 | A novel missense variant affecting function, c.323C>T (p.(Ser108Leu)), was identified in MYT1, in a patient presenting with a severe form of OAVS. MYT1 overexpression downregulated all RA receptors genes in vitro. | 28612832 |
| Type | IDs |
|---|---|
| Synonymous | C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2H2C1, ZC2HC4A |
| Gene |
UniProtKB-ID:
MYT1_HUMAN
UniprotKB:
Q01538
UniParc:
UPI0002065984,
UPI000012FBFA
EMBL:
BC053638,
M96980,
CH471077,
AB020642,
AL121581,
AB028973
Ensembl:
ENSG00000196132,
ENSG00000276876
KO:
hsa:4661
|
| Nucleutide sequences |
EMBL-CDS:
EAW75155.1,
AAH53638.1,
BAA83002.1,
BAA74858.2,
EAW75157.1,
AAA59897.1,
EAW75158.1
Ensembl_TRS:
ENST00000536311,
ENST00000328439,
ENST00000650655,
ENST00000613234,
ENST00000616648
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000477771,
ENSP00000442412,
ENSP00000327465,
ENSP00000498616,
ENSP00000483021
RefSeq:
NP_004526.1
|
| Others |
UniRef100:
UniRef100_Q01538
UniRef90:
UniRef90_Q01538
UniRef50:
UniRef50_Q8CFC2
UniGene:
Hs.279562
CCDS:
CCDS13558.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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