| Type | Description |
|---|---|
| Definition | myosin VI |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:23:00 | Clinical Characteristics and In Vitro Analysis of MYO6 Variants Causing Late-Onset Progressive Hearing Loss. | 32143290 |
| 2020-09-19 16:25:00 | Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function. | 31744880 |
| 2020-09-19 16:23:00 | A humanized mouse model, demonstrating progressive hearing loss caused by MYO6 p.C442Y, is inherited in a semi-dominant pattern. | 31103816 |
| 2020-03-07 12:04:00 | We identified and classified a pathogenic GFI1 variant and a likely pathogenic variant in MYO6 which together explain the complex phenotypes seen in this family. | 32066420 |
| 2020-03-07 11:54:00 | There is coordinated action of myosin VI and CLCa at the apical surface where these proteins are essential for fission of clathrin-coated pits. Myosin VI and Huntingtin-interacting protein 1-related protein (Hip1R) are mutually exclusive interactors with CLCa, and suggest a model for the sequential function of myosin VI and Hip1R in actin-mediated clathrin-coated vesicle budding. | 31672988 |
| Type | IDs |
|---|---|
| Synonymous | DFNA22, DFNB37 |
| Gene |
UniProtKB-ID:
MYO6_HUMAN
UniprotKB:
Q9UM54
UniParc:
UPI0000EADF48,
UPI0002423F1E,
UPI0000EADF47,
UPI00000727CF,
UPI0000EADF49,
UPI000012FB94
EMBL:
AF229083,
AF229103,
AF229098,
AF229085,
AF229111,
U90236,
AF229107,
AF229099,
AF229093,
AF229091,
AF229082,
AF229095,
AF229086,
AL109897,
AF229089,
AF229101,
AF229102,
AF229100,
AF229092,
AF229097,
AB002387,
BC146764,
CH471051,
AF229110,
AF229109,
AF229094,
AF229104,
AF229087,
AF229090,
AF229105,
AF229108,
AF229106,
AF229084,
AF229096,
BP333853,
AL136093,
AF229088
Ensembl:
ENSG00000196586
KO:
hsa:4646
|
| Nucleutide sequences |
EMBL-CDS:
EAW48731.1,
AAK00229.1,
AAI46765.1,
BAA20843.2,
AAC51654.2,
EAW48730.1
Ensembl_TRS:
ENST00000369985,
ENST00000369977,
ENST00000615563
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000359002,
ENSP00000478013,
ENSP00000358994
RefSeq:
NP_001355795.1,
NP_001355794.1,
NP_001355067.1,
XP_005248778.1,
NP_004990.3,
NP_001287828.1,
NP_001355066.1,
XP_024302215.1,
XP_005248781.1,
NP_001355068.1,
NP_001355065.1,
NP_001355069.1,
XP_016866388.1,
XP_005248779.1
|
| Others |
UniRef100:
UniRef100_Q9UM54
UniRef90:
UniRef90_Q9UM54
UniRef50:
UniRef50_Q9UM54
UniGene:
Hs.149387
CCDS:
CCDS75481.1,
CCDS34487.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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