| Type | Description |
|---|---|
| Definition | metallothionein 1M |
| Date | Results | Publications |
|---|---|---|
| 2019-11-02 10:36:00 | MT1M can suppress hepatocellular carcinoma cell proliferation and induce apoptosis through downregulating Bcl-2, upregulating Bax, and enhancing Caspase-3 activity. | 29461597 |
| 2019-08-24 12:34:00 | In clear cell renal cell carcinoma (RCC) MT1E, MT1G and MT1M expression was higher than that noted in other histological tumor subtypes (all P<0.0500). In addition, some associations were observed between metabolic syndromerelated clinical parameters and promoter methylation or gene expression | 31002354 |
| 2019-03-02 10:52:00 | MiR-545-3p, which served as a tumor promoter, post-transcriptionally regulate MT1M in HCC through binding to its untranslated region (3'UTR). | 30227328 |
| 2018-03-17 10:26:00 | Results found that MT1M is downregulated in hepatocellular carcinoma (HCC) tumors, and it suppressed HCC tumorigenesis possibly by inducing cell cycle arrest, enhancing apoptosis and inhibiting cell migration and invasion. These findings provide evidence that MT1M might be a tumor suppressor in HCC tumorigenesis. | 28380433 |
| 2017-03-04 12:08:00 | Low MT1M expression is associated with poor hepatocellular carcinoma prognosis following curative resection. | 27808371 |
| Type | IDs |
|---|---|
| Synonymous | MT-1M, MT-IM, MT1, MT1K |
| Gene |
UniProtKB-ID:
MT1M_HUMAN,
A0A024R6T4_HUMAN
UniprotKB:
Q8N339,
A0A024R6T4
UniParc:
UPI00000721AD,
UPI0000071D97
EMBL:
AF348671,
AF136177,
BC103841,
BC028280,
CH471092
Ensembl:
ENSG00000205364
KO:
hsa:4499
|
| Nucleutide sequences |
EMBL-CDS:
AAI03842.1,
AAH28280.1,
AAP97267.1,
AAL83902.1,
EAW82875.1,
EAW82876.1
Gene_ORFName:
hCG_2025554
Ensembl_TRS:
ENST00000379818
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000369146
RefSeq:
NP_789846.2
|
| Others |
UniRef100:
UniRef100_A0A024R6T4,
UniRef100_Q8N339
UniRef90:
UniRef90_Q8N339
UniRef50:
UniRef50_P13640
UniGene:
Hs.647370
CCDS:
CCDS42166.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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