| Type | Description |
|---|---|
| Definition | APC-like |
| Date | Results | Publications |
|---|---|---|
| 2018-07-21 12:17:00 | Novel requirement for APC in Axin regulation through phosphorylation both prevents signaling in the Wnt-off state and promotes signaling immediately following Wnt stimulation. | 29408853 |
| 2017-08-05 11:49:00 | in the adult intestine, Ebd acts independently of Ewg in physiological Wnt signaling, but cooperates with Ewg to induce the hyperactivation of Wnt target gene expression following Apc1 loss. These findings have relevance for human tumorigenesis, as Jerky (JRK/JH8), the human Ebd homolog, promotes Wnt pathway hyperactivation and is overexpressed in colorectal, breast, and ovarian cancers | 28708826 |
| 2017-05-13 19:25:00 | We conclude that even in the unstimulated state, a pool of Axin forms membrane-proximal puncta that are dependent on Apc, and that membrane association regulates both Axin levels and Axin's role in the rapid activation of signaling that follows Wnt exposure. | 27959917 |
| 2013-07-27 11:25:00 | Data indicate that Ras is not required for Wnt signaling activation after APC loss. | 23570874 |
| 2013-07-13 13:16:00 | Drosophila and vertebrate APCs exhibit highly related activities and mechanisms and directly collaborate with formins such as diaphanous. | 23558679 |
| Type | IDs |
|---|---|
| Synonymous | APC, APC1, Apc1, CG1451, D-APC, D-APC1, DAPC, Dm APC1, Dmel\CG1451, apc, apc 1, apc1, d-APC, dAPC, dAPC1, dApc, dapc1 |
| Gene |
UniProtKB-ID:
Q9VAS9_DROME,
A0A126GV30_DROME
UniprotKB:
Q9VAS9,
A0A126GV30
UniParc:
UPI000008180C,
UPI0006AD0989
EMBL:
AE014297
EnsemblGenome:
FBgn0015589
KO:
dme:Dmel_CG1451
|
| Nucleutide sequences |
EMBL-CDS:
AGB96426.1,
AAF56820.1,
ALI30649.1
Gene_ORFName:
Dmel_CG1451,
CG1451,
CG1451,
Dmel_CG1451
EnsemblGenome_TRS:
FBtr0085351,
FBtr0336767,
FBtr0445314
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0084720,
FBpp0307743,
FBpp0401491
RefSeq:
NP_001303423.1,
NP_001263046.1,
NP_477152.1
|
| Others |
UniRef100:
UniRef100_A0A126GV30,
UniRef100_Q9VAS9
UniRef90:
UniRef90_A0A126GV30,
UniRef90_Q9VAS9
UniRef50:
UniRef50_Q9VAS9,
UniRef50_A0A126GV30
UniGene:
Dm.4863
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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