| Type | Description |
|---|---|
| Definition | Hepatocyte nuclear factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:51:00 | Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A. | 31875549 |
| 2019-08-03 12:25:00 | establish dHNF4 as a regulator of the adult metabolic state | 30554999 |
| 2017-11-18 13:36:00 | Here the authors report that loss of Drosophila HNF4 recapitulates hallmark symptoms of Maturity Onset Diabetes of the Young 1 (MODY1), including adult-onset hyperglycemia, glucose intolerance and impaired glucose-stimulated insulin secretion (GSIS). | 27185732 |
| 2016-08-20 12:12:00 | Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 mutants, and protein levels for dHNF4 are reduced in sir2 mutant animals. Sir2 exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions. | 27058248 |
| 2010-01-21 00:00:00 | Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production. | 19254568 |
| Type | IDs |
|---|---|
| Synonymous | CG9310, DmHNF4, Dmel\CG9310, HNF-4, HNF-4(D), HNF4, HNF4alpha, Hnf-4, Hnf-4h, NHF4, NR2A4, dHNF-4, dHNF4 |
| Gene |
UniProtKB-ID:
HNF4_DROME,
X2J9X1_DROME
UniprotKB:
P49866,
X2J9X1
UniParc:
UPI00001249B6,
UPI00000846DB,
UPI0001505C9B,
UPI000000C071
EMBL:
AE014134,
U70874,
BT001800,
BT003533,
BT088848
EnsemblGenome:
FBgn0004914
KO:
dme:Dmel_CG9310
|
| Nucleutide sequences |
EMBL-CDS:
AAN71555.1,
ACS68165.1,
AAO39537.1,
AAN10680.1,
AAB09592.1,
AAF52702.2,
ABV53653.1,
AAF52703.2,
AHN54272.1
Gene_ORFName:
CG9310,
Dmel_CG9310,
CG9310
EnsemblGenome_TRS:
FBtr0079747,
FBtr0336633,
FBtr0112846,
FBtr0079748,
FBtr0344784
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0079349,
FBpp0111759,
FBpp0079350,
FBpp0307616,
FBpp0311113
RefSeq:
NP_723413.1,
NP_476887.2,
NP_723414.2,
NP_001097126.1,
NP_001285758.1
|
| Others |
UniRef100:
UniRef100_P49866,
UniRef100_P49866-3
UniRef90:
UniRef90_P49866-3,
UniRef90_P49866
UniRef50:
UniRef50_P49866
UniGene:
Dm.4524
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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