| Type | Description |
|---|---|
| Definition | mutS homolog 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 10:12:00 | Decreased expression of HCP5 in biochemical premature ovarian insufficiency (bPOI) contributed to dysfunctional granulosa cells by regulating MSH5 transcription and DNA damage repair via the interaction with YB1, providing a novel epigenetic mechanism for POI pathogenesis. | 32112110 |
| 2017-10-28 11:28:00 | Findings indicate that carriers of the MSH5 rs707939 T allele, the MSH2 rs6544991 C allele, the MSH3 rs6151627 and rs6151670 G alleles, and the MSH3 rs7709909 T allele have poor toxicity tolerance to platinum-based chemotherapy in non-small cell lung cancer patients. | 28093084 |
| 2017-05-20 11:23:00 | From sanger sequencing of MSH5 in 200 sporadic POI patients, we identified three heterozygous mutations . Considering the heterozygous p.D487Y carrier in the POI pedigree was fertile, the causality of the three heterozygous mutations in POI need more evidence | 28175301 |
| 2015-10-24 11:31:00 | our data point to the existence of a functional interplay between hMSH5 and FANCJ in double-strand break repair induced by replication stress. | 26055704 |
| 2014-04-12 10:46:00 | the roles of hMSH5 variants in the processes of DNA damage response and repair | 24023853 |
| Type | IDs |
|---|---|
| Synonymous | G7, MUTSH5, NG23, POF13 |
| Gene |
UniProtKB-ID:
MSH5_HUMAN,
A0A024RCV6_HUMAN,
A0A024RCM1_HUMAN
UniprotKB:
O43196,
A0A024RCV6,
A0A024RCM1
UniParc:
UPI0000074560,
UPI000013D6DA,
UPI0000070722,
UPI000012F5F7
EMBL:
AF048990,
AF048991,
AF048988,
AF070076,
AF070072,
BA000025,
AF070079,
AF070074,
CR936239,
KY500473,
CH471081,
AL662834,
CR925765,
AF070073,
KY500465,
AF070075,
BC001358,
AF048986,
AF034759,
AF070077,
AF070071,
AF070078,
AF048989,
AL662899,
KY500471,
AF134726,
BT007200,
AY943816,
BC041031,
CR759787,
BC002498,
AF129756,
KY500468
Ensembl:
ENSG00000204410,
ENSG00000230961,
ENSG00000230293,
ENSG00000227314,
ENSG00000235222
KO:
hsa:4439
|
| Nucleutide sequences |
EMBL-CDS:
AAH02498.1,
AAC62534.1,
AAX20111.1,
AAH41031.1,
AAC70067.1,
AAD21822.1,
AAD18072.1,
AAC62533.1,
EAX03514.1,
AAH01358.1,
AAB87632.1,
AAC70066.1,
BAB63375.1,
AAP35864.1,
EAX03512.1,
EAX03515.1,
AQY76938.1,
EAX03513.1,
EAX03518.1,
AQY76946.1,
AQY76944.1,
EAX03516.1,
AQY76941.1
Gene_ORFName:
hCG_2001570,
hCG_2001570
Ensembl_TRS:
ENST00000436091,
ENST00000375750,
ENST00000375740,
ENST00000448617,
ENST00000427735,
ENST00000416549,
ENST00000441395,
ENST00000436192,
ENST00000375703,
ENST00000412070,
ENST00000457742,
ENST00000375755,
ENST00000420731,
ENST00000435700,
ENST00000441401,
ENST00000419269,
ENST00000456839
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000409181,
ENSP00000394649,
ENSP00000406868,
ENSP00000364855,
ENSP00000364903,
ENSP00000364892,
ENSP00000406269,
ENSP00000396509,
ENSP00000400187,
ENSP00000364908,
ENSP00000388037,
ENSP00000394017,
ENSP00000404892,
ENSP00000407047,
ENSP00000387609,
ENSP00000399721,
ENSP00000402659
RefSeq:
NP_002432.1,
NP_079535.4,
NP_751897.1,
NP_751898.1
|
| Others |
UniRef100:
UniRef100_A0A024RCV6,
UniRef100_O43196
UniRef90:
UniRef90_O43196,
UniRef90_O43196-4
UniRef50:
UniRef50_O43196
UniGene:
Hs.647011
CCDS:
CCDS4720.1,
CCDS34410.1,
CCDS34409.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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