| Type | Description |
|---|---|
| Definition | Isocitrate dehydrogenase |
| Date | Results | Publications |
|---|---|---|
| 2017-09-23 12:30:00 | trimethyl isocitrate (TIC), a cell permeable isocitrate, protected mammalian DJ-1 null DA cells from oxidative stress in an IDH-dependent manner. These results suggest that isocitrate and its derivatives are novel treatments for Parkinson's disease associated with DJ-1 dysfunction. | 28827794 |
| 2015-03-21 10:12:00 | We identified the fly homolog of D-2-hydroxyglutaric acid dehydrogenase (CG3835), which metabolizes D-2HG, and showed that coexpression of this enzyme with mutant Idh abolishes mutant Idh-associated phenotype | 25398939 |
| Type | IDs |
|---|---|
| Synonymous | CG7176, CT22171, Dmel\CG7176, ICDH, IDH, IDH-NADP, Idh-NADP, cIdh, idh, isocitrate dehydrogenase, l(3)L3852 |
| Gene |
UniProtKB-ID:
Q9VSI6_DROME,
Q8IQA7_DROME,
Q7KUB0_DROME,
B7Z0E0_DROME,
Q7KUB1_DROME
UniprotKB:
Q9VSI6,
Q8IQA7,
Q7KUB0,
B7Z0E0,
Q7KUB1
UniParc:
UPI0000083315,
UPI00000845B3,
UPI0000124904,
UPI00001E1971,
UPI000002A18E
EMBL:
AY047505,
AE014296,
BT099506
EnsemblGenome:
FBgn0001248
KO:
dme:Dmel_CG7176
|
| Nucleutide sequences |
EMBL-CDS:
AAF50433.1,
ACL83266.1,
AAO41266.1,
AAN12003.2,
AAK77237.1,
ACU24746.1,
AAN12002.1,
AAN12004.1,
AAF50435.1,
ACL83265.2,
AAF50434.1
Gene_ORFName:
CG7176,
Dmel_CG7176,
Dmel_CG7176,
CG7176,
CG7176,
Dmel_CG7176,
CG7176,
Dmel_CG7176,
Dmel_CG7176,
CG7176
EnsemblGenome_TRS:
FBtr0076673,
FBtr0114548,
FBtr0076669,
FBtr0114549,
FBtr0076671,
FBtr0076668,
FBtr0076667,
FBtr0333058,
FBtr0076670
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0113041,
FBpp0113040,
FBpp0076396,
FBpp0076392,
FBpp0076394,
FBpp0076390,
FBpp0076391,
FBpp0305272,
FBpp0076393
RefSeq:
NP_729370.1,
NP_001137911.1,
NP_788476.1,
NP_729367.1,
NP_652044.1,
NP_729369.2,
NP_729366.1,
NP_001137910.2,
NP_729368.1
|
| Others |
UniRef100:
UniRef100_B7Z0E0,
UniRef100_Q9VSI6,
UniRef100_Q7KUB1
UniRef90:
UniRef90_B7Z0E0
UniRef50:
UniRef50_B7Z0E0
UniGene:
Dm.4678
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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