| Type | Description |
|---|---|
| Definition | Ret oncogene |
| Date | Results | Publications |
|---|---|---|
| 2018-04-14 11:20:00 | Gfrl shares the same enteric nervous system (ENS) and feeding defects with Ret, suggesting that Ret and Gfrl might function together via a common ligand. We identified the TGFbeta family member Maverick (Mav) as a ligand for Gfrl and a Mav chromosomal deficiency displayed similar embryonic ENS defects. Results suggest that the Ret and Gfrl families co-evolved before the separation of invertebrate and vertebrate lineages. | 29361562 |
| 2017-11-25 14:14:00 | We demonstrate that this phospho-S909 arises from an intrinsic RET dual-specificity kinase activity and show that an equivalent serine is required for RET signaling in Drosophila. Our findings reveal dual-specificity and allosteric components for the mechanism of RET activation and signaling with direct implications for drug discovery | 28009299 |
| 2017-10-21 12:24:00 | Mechanistically, Ret is engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases. | 28899900 |
| 2016-01-02 10:04:00 | Ret as a regulator in dendrite patterning and adhesion distinct from its role in axon guidance, is proposed. | 25764303 |
| 2014-04-19 10:11:00 | A signaling active version of Ret (Ret(MENB) rescues muscle degeneration, disintegration of mitochondria and ATP content of Pink1 mutants. | 24473149 |
| Type | IDs |
|---|---|
| Synonymous | CG1061, CG14396, D-ret, DRET, DRet, DmHD-59, DmRet, Dmel\CG14396, Dret, HD-59, MEN2, RET, Reto, dRET, dRet, dret, ret |
| Gene |
UniProtKB-ID:
Q7KT06_DROME
UniprotKB:
Q7KT06
UniParc:
UPI00000074EE
EMBL:
AE014134
EnsemblGenome:
FBgn0011829
KO:
dme:Dmel_CG14396
|
| Nucleutide sequences |
EMBL-CDS:
AAF53977.3,
AAF53978.2,
AAN11101.1
Gene_ORFName:
Dmel_CG14396,
CG14396
EnsemblGenome_TRS:
FBtr0081494,
FBtr0081495,
FBtr0081493
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0081022,
FBpp0081023,
FBpp0081021
RefSeq:
NP_724315.1,
NP_724316.1,
NP_477044.1
|
| Others |
UniRef100:
UniRef100_Q7KT06
UniRef90:
UniRef90_Q7KT06
UniRef50:
UniRef50_Q7KT06
UniGene:
Dm.482
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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