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43673 dco

43673

dco

discs overgrown

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition discs overgrown

研究结论

Date Results Publications
2020-09-26 13:09:00 DAnkrd49 and Bdbt act via Casein kinase Iepsilon to regulate planar polarity in Drosophila. 32750048
2020-02-29 10:59:00 The authors conclude that Casein Kinase Iepsilon phosphorylation acts as a switch, promoting Strabismus mobility and Dishevelled immobility, thus enhancing sorting of these proteins to opposite cell edges. 31090542
2019-06-08 11:08:00 Phosphorylation of PER residue S589 stabilizes and activates PER inhibitory function in the presence of TIM, but promotes PER degradation in its absence. The role of DBT in regulating PER activity, stabilization and degradation ensures that these events are chronologically and biochemically linked, and contributes to the timing of an essential delay that influences the period of the circadian clock. 29611807
2019-06-08 10:43:00 DBT plays a dual role on PER in control of this core mechanism (i) by relieving the effects of PER on the transcriptional repression when it targets nuclear PER for degradation and (ii) by delaying PER's nuclear localization when targeting its degradation in the cytoplasm. 30769795
2016-05-07 10:03:00 results demonstrate that Bride of Doubletime (BDBT) interacts with doubletime(DBT)in a manner requiring the DBT nuclear localization signal for nuclear localization and that the interaction is required to produce a fully functional circadian complex 26082158

名称对应

Type IDs
Synonymous 0538/13, 0915/10, 1396/02, 1447/01, 1460/09, CG2048, CK1delta/epsilon, CK1epsilon, CKIepsilon, DBT, DBT/CK1epsilon, DCO, DCO/CKIe, Dbt, Dco, Dco/CK1, Dmel\CG2048, ck1epsilon, dCKIepsilon, dbt, dco-1, ddbt, l(3)S053813, l(3)S144701, l(3)dco, l(3)dco-1, l(3)discs overgrown, l(3)discs overgrown-1, l(3)j3B9, l(3)rK215
Gene
UniProtKB-ID: DCO_DROME, A0A0B4KHX3_DROME
UniprotKB: O76324, A0A0B4KHX3
UniParc: UPI0000084086
EMBL: AE014297, AF132558, AF192484, AF055583
EnsemblGenome: FBgn0002413
KO: dme:Dmel_CG2048
Nucleutide sequences
EMBL-CDS: AAC39134.1, AAF57109.1, AAD27857.1, AAF57110.1, AAF27346.1, AGB96511.1, QCD25211.1
Gene_ORFName: CG2048, CG2048, Dmel_CG2048
EnsemblGenome_TRS: FBtr0473370, FBtr0334548, FBtr0085743, FBtr0085742, FBtr0085744, FBtr0085744, FBtr0334548, FBtr0473370, FBtr0085742, FBtr0085743
Protein sequencees
EnsemblGenome_PRO: FBpp0085105, FBpp0306615, FBpp0422974, FBpp0085106, FBpp0085104, FBpp0085104, FBpp0085105, FBpp0422974, FBpp0306615, FBpp0085106
RefSeq: NP_001356928.1, NP_524602.1, NP_733415.1, NP_001263132.1, NP_733414.1
Others
UniRef100: UniRef100_O76324
UniRef90: UniRef90_O76324
UniRef50: UniRef50_O76324
UniGene: Dm.1901

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