Tnni3k - TNNI3 interacting kinase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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435766 Tnni3k

基因描述

Type	Description
Definition	TNNI3 interacting kinase

研究结论

Date	Results	Publications
2020-02-01 11:12:00	This may be explained by the observation that Tnni3k function in mice converges with oxidative stress to regulate mononuclear diploid cardiomyocyte frequency.	31589606
2015-09-26 21:45:00	using novel genetic animal models and newly developed small-molecule TNNI3K inhibitors, we demonstrated that TNNI3K-mediated IR injury occurs through impaired mitochondrial function and is in part dependent on p38 MAPK.	24899531
2013-05-11 13:04:00	Our data provide the first evidence for a role of Tnni3k in controlling the electrocardiographic PR interval indicating a function of Tnni3k in atrio-ventricular conduction	23236294
2011-08-13 10:48:00	Data identified Tnni3k, Fpgt and H28 as likely likely candidates for Vms1.	21525387
2010-01-21 00:00:00	Tnni3k plays a critical role in the modulation of different forms of heart disease, and this protein may provide a novel target for therapeutic intervention.	19763165

名称对应

Type	IDs
Synonymous	Cark, D830019J24Rik
Gene	UniProtKB-ID: TNI3K_MOUSE UniprotKB: Q5GIG6 UniParc: UPI0000565C41, UPI0000D637CE EMBL: BC139368, AC125097, AC124174, BC139394, AY526095, AC144762, AY526096 Ensembl: ENSMUSG00000040086 KO: mmu:435766
Nucleutide sequences	EMBL-CDS: AAS98608.1, AAI39395.1, AAI39369.1, AAS98609.1 Ensembl_TRS: ENSMUST00000064076, ENSMUST00000143410
Protein sequencees	Ensembl_PRO: ENSMUSP00000122478, ENSMUSP00000070561 RefSeq: XP_011238456.1, XP_011238457.1, NP_796040.3
Others	UniRef100: UniRef100_Q5GIG6 UniRef90: UniRef90_Q5GIG6 UniRef50: UniRef50_Q59H18-3 UniGene: Mm.210428 CCDS: CCDS17928.1

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
33084860	The prevalent I686T human variant and loss-of-function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice. Hum Mol Genet Peiheng Gan , Catalin Baicu , Hirofumi Watanabe , Kristy Wang , Ge Tao , Daniel P Judge , Michael R Zile , Takako Makita , Rupak Mukherjee , Henry M Sucov	2021-01-06	-
31589606	Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency. PLoS Genet Peiheng Gan , Michaela Patterson , Alexa Velasquez , Kristy Wang , Di Tian , Jolene J Windle , Ge Tao , Daniel P Judge , Takako Makita , Thomas J Park , Henry M Sucov	2019-10-01	-
28783163	Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat. Genet. Michaela Patterson , Lindsey Barske , Ben Van Handel , Christoph D Rau , Peiheng Gan , Avneesh Sharma , Shan Parikh , Matt Denholtz , Ying Huang , Yukiko Yamaguchi , Hua Shen , Hooman Allayee , J Gage Crump , Thomas I Force , Ching-Ling Lien , Takako Makita , Aldons J Lusis , S Ram Kumar , Henry M Sucov	2017-09-01	-
25787061	TNNI3K in cardiovascular disease and prospects for therapy. J. Mol. Cell. Cardiol. Annalisa Milano , Elisabeth M Lodder , Connie R Bezzina	2015-05-01	Tnni3k
24899531	Troponin I-interacting protein kinase: a novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease. Circ. J. Hind Lal , Firdos Ahmad , Shan Parikh , Thomas Force	2014-01-01	-
24132636	Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart. Sci Transl Med Ronald J Vagnozzi , Gregory J Gatto , Lara S Kallander , Nicholas E Hoffman , Karthik Mallilankaraman , Victoria L T Ballard , Brian G Lawhorn , Patrick Stoy , Joanne Philp , Alan P Graves , Yoshiro Naito , John J Lepore , Erhe Gao , Muniswamy Madesh , Thomas Force	2013-10-16	Tnni3k
23085512	Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction. J. Mol. Cell. Cardiol. Hao Tang , Kunhong Xiao , Lan Mao , Howard A Rockman , Douglas A Marchuk	2013-01-01	-
23236294	Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction. PLoS Genet. Elisabeth M Lodder , Brendon P Scicluna , Annalisa Milano , Albert Y Sun , Hao Tang , Carol Ann Remme , Perry D Moerland , Michael W T Tanck , Geoffrey S Pitt , Douglas A Marchuk , Connie R Bezzina	2012-01-01	Tnni3k, TNNI3K
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21677750	A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley	2011-06-15	-

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