| Type | Description |
|---|---|
| Definition | argininosuccinate lyase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:28:00 | Mechanistically, KLF7 transcriptionally activated argininosuccinate lyase (ASL), which was observed highly expressed in glioma tissues. KLF7 potentiates polyamine biosynthesis and glioma cell growth via transcriptionally activates ASL. | 31018905 |
| 2019-12-07 11:06:00 | Compound heterozygous p.Lys69Arg and p.Arg213 * mutations that resulted in reduced ASL enzyme activity were found in a patient with ASLD. | 31183366 |
| 2018-03-17 11:35:00 | The remaining five patients were diagnosed with neonatal intrahepatic cholestasis due to citrin deficiency, and have respectively carried mutations of the SLC25A13 gene including [c.851-854delGTAT+c.851-854delGTAT], [c.851-854delGTAT+IVS6+5G>A], [c.851-854delGTAT+IVS16ins3kb], [c.851-854delGTAT+IVS6-11A>G] and [c.851-854delGTAT+c.1638-1660dup23] | 28981931 |
| 2017-04-15 12:04:00 | Overexpression of ASL may be a contributing factor in drug resistance for arginine deprivation therapy. | 28035420 |
| 2017-04-15 10:59:00 | ASL-targeting shRNA-induced growth inhibition is associated with decreased cyclin A2 expression and Nitric oxide content in colon cancer. | 27840980 |
| Type | IDs |
|---|---|
| Synonymous | ASAL |
| Gene |
UniProtKB-ID:
ARLY_HUMAN,
A0A024RDL8_HUMAN,
A0A0S2Z316_HUMAN
UniprotKB:
P04424,
A0A024RDL8,
A0A0S2Z316
UniParc:
UPI000053FD0C,
UPI000053FD0B,
UPI0000001634
EMBL:
Y00753,
AF376770,
BC008195,
M21006,
M14218,
M21007,
AC068533,
KU177921,
BC033146,
CH471140,
J03058,
KU177920,
M57638
Ensembl:
ENSG00000126522
KO:
hsa:435
|
| Nucleutide sequences |
EMBL-CDS:
AAA51788.1,
AAH08195.1,
AAA51786.1,
AAA51787.1,
AAA35566.1,
AAL57276.1,
CAA68722.1,
AAH33146.1,
EAX07946.1,
EAX07945.1,
ALQ33378.1,
ALQ33379.1
Gene_ORFName:
hCG_18702
Ensembl_TRS:
ENST00000380839,
ENST00000673518,
ENST00000395331,
ENST00000304874,
ENST00000395332
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000378740,
ENSP00000499889,
ENSP00000307188,
ENSP00000370219,
ENSP00000378741
RefSeq:
NP_001020114.1,
NP_000039.2,
NP_001020115.1,
NP_001020117.1
|
| Others |
UniRef100:
UniRef100_P04424,
UniRef100_P04424-3
UniRef90:
UniRef90_P04424,
UniRef90_P04424-3
UniRef50:
UniRef50_P04424
UniGene:
Hs.632015
CCDS:
CCDS5531.1,
CCDS47598.1,
CCDS47597.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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