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43392 htt

43392

htt

huntingtin

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition huntingtin

研究结论

Date Results Publications
2020-06-06 11:14:00 Application of a behavioral platform to screen for clock-regulated Huntington's Disease suppressors, identifies a role for Heat Shock Protein 70/90 Organizing Protein (Hop). Hop knockdown paradoxically reduces mutant Htt aggregation and toxicity. This reveals a clock-regulated molecular and cellular pathway that links clock function to neurodegenerative disease. 30943415
2020-02-01 12:47:00 Loss of CrebA also partially suppresses mHtt effects on behavior and cell loss and restoration of CrebA can suppress Atx2 effects. Our results indicate a prominent role of Atx2 in mediating mHtt pathology, specifically via its regulation of CrebA, defining a novel molecular pathway in Huntington's disease pathogenesis. 31593562
2018-10-13 11:31:00 Jp modifies the neuronal degeneration in a Drosophila model of Huntington's disease, and it has uncoveedr an unsuspected functional relationship with the Notch pathway. 29208631
2018-05-12 11:33:00 Data strongly suggest that mutant Htt expression exclusively in all the CNS and PNS neurons leads to fluctuation of body weight, carbohydrate and protein stores, global lipid levels along with the intracellular lipid deposits through its effect on the integrated process of metabolic homeostasis. These results also support the idea that lipid metabolism remains centrally affected in HD leading to altered body weight. 27506601
2018-02-24 11:12:00 These results therefore identify native Htt as a regulator of synaptic capture and neuropeptide storage. 28129919

名称对应

Type IDs
Synonymous CG9995, DmHtt, Dmel\CG9995, HD, HTT, Htt, dHtt, dhtt
Gene
UniProtKB-ID: Q9V3N4_DROME
UniprotKB: Q9V3N4
UniParc: UPI0000077AE8
EMBL: AE014297, AF146362, AF147779
EnsemblGenome: FBgn0027655
KO: dme:Dmel_CG9995
Nucleutide sequences
EMBL-CDS: AGB96421.1, AAF03256.1, AAF03255.1, AAF56808.1
Gene_ORFName: Dmel_CG9995, CG9995
EnsemblGenome_TRS: FBtr0085310, FBtr0336788
Protein sequencees
EnsemblGenome_PRO: FBpp0307764, FBpp0084679
RefSeq: NP_001263041.1, NP_651629.1
Others
UniRef100: UniRef100_Q9V3N4
UniRef90: UniRef90_Q9V3N4
UniRef50: UniRef50_Q9V3N4
UniGene: Dm.1357

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