| Type | Description |
|---|---|
| Definition | afadin, adherens junction formation factor |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 11:46:00 | Afadin binding with interaction partners in adipocytes, among which HDAC6 preferentially interacts with phosphorylated Afadin and acts as a key intermediate to suppress insulin receptor protein levels. | 31264358 |
| 2020-03-21 10:18:00 | The authors report here that the homophilic receptor PTPRK is stabilized at cell-cell contacts in epithelial cells. PTPRK directly and selectively dephosphorylates at least five substrates, including Afadin, PARD3 and delta-catenin family members, which are all important cell-cell adhesion regulators. | 30924770 |
| 2019-03-02 12:14:00 | high levels of both Claudin-2 and Afadin in primary tumors were associated with poor disease-specific survival, relapse-free survival, lung-specific relapse, and liver-specific relapse | 30692208 |
| 2018-07-14 10:05:00 | CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. | 29159771 |
| 2018-04-28 11:12:00 | AF6 employs a non-canonical, evolutionarily conserved alpha-helix to bind RAS, unique to AF6 and the classical RASSF effectors. | 29062045 |
| Type | IDs |
|---|---|
| Synonymous | AF6, MLL-AF6, MLLT4, l-afadin |
| Gene |
UniProtKB-ID:
AFAD_HUMAN,
A8MQ02_HUMAN,
G1UI22_HUMAN,
J3KN01_HUMAN
UniprotKB:
P55196,
A8MQ02,
G1UI22,
J3KN01
UniParc:
UPI000222EEA2,
UPI0000711FDA,
UPI0000125659,
UPI000002A36B,
UPI00045D52FC,
UPI000047089C,
UPI0000711FD9,
UPI0001D3BD11,
UPI0000367407
EMBL:
AB621809,
AL731868,
U02478,
AL161973,
AB011399,
AB209420,
CH471051,
AL009178,
KF458344,
AL049698
Ensembl:
ENSG00000130396
KO:
hsa:4301
|
| Nucleutide sequences |
EMBL-CDS:
CAB82312.1,
EAW47482.1,
BAA32485.1,
BAA32484.1,
AAC50059.1,
BAD92657.1,
BAA32483.1,
BAK64145.1
Ensembl_TRS:
ENST00000400822,
ENST00000447894,
ENST00000392112,
ENST00000392108,
ENST00000366806,
ENST00000351017
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000383623,
ENSP00000375956,
ENSP00000375960,
ENSP00000404595,
ENSP00000355771,
ENSP00000252692
RefSeq:
NP_001035089.1,
XP_006715557.1,
XP_006715554.1,
XP_016866367.1,
XP_016866376.1,
NP_001193937.1,
NP_001353249.1,
XP_005267054.1,
NP_001373817.1,
NP_001353248.1,
NP_001278893.1,
XP_016866371.1,
XP_016866374.1,
XP_016866370.1,
XP_016866373.1,
XP_016866375.1,
XP_016866369.1,
NP_001353250.1
|
| Others |
UniRef100:
UniRef100_G1UI22,
UniRef100_J3KN01,
UniRef100_P55196,
UniRef100_A8MQ02
UniRef90:
UniRef90_A8MQ02,
UniRef90_O35889,
UniRef90_G1UI22,
UniRef90_P55196
UniRef50:
UniRef50_P55196,
UniRef50_O35889,
UniRef50_P55196-1
UniGene:
Hs.614974,
Hs.728849,
Hs.741785
CCDS:
CCDS75553.1,
CCDS47517.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员