| Type | Description |
|---|---|
| Definition | Nicotinamide mononucleotide adenylyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 10:41:00 | Highwire downregulates dNmnat to promote evoked synaptic release, suggesting that Highwire balances the axoprotective and synapse-inhibitory functions of dNmnat. | 30692130 |
| 2019-05-04 12:02:00 | On H2O2 challenge tests, Nmnat overexpression was sufficient to increase the survival time and movement capacity of Drosophila, which was probably due to its protection against oxidative stress. On rotenone induced mitochondrial dysfunction, Nmnat overexpression also showed better health span and movement capacity than the control group. | 29727704 |
| 2018-12-22 10:15:00 | a critical role for nicotinamide mononucleotide adenylyltransferase (Nmnat) in maintaining the integrity and function of peripheral sensory neurons, is reported. | 29716954 |
| 2017-05-13 14:53:00 | Thus axon injury seems to both turn on NP, but also dampen it by activating mitochondrial fission. We also identified caspases as negative regulators of axon injury-mediated NP, so mitochondrial fission could control NP through caspase activation. In addition to negative regulators of NP, we found that nicotinamide mononucleotide adenylyltransferase (Nmnat) is absolutely required for this type of NP. | 27923046 |
| 2016-07-02 11:58:00 | Nmnat is alternatively spliced into two mRNA variants, RA and RB, which translate to protein isoforms with neuroprotective capacities. | 26616331 |
| Type | IDs |
|---|---|
| Synonymous | 3R4, AAL90149, CG13645, DmNMNAT, DmNmnat, Dmel\CG13645, NMNAT, Nmnat1, NmnatB, dNmnat, nmnat |
| Gene |
UniProtKB-ID:
Q9VC03_DROME,
Q7KS06_DROME,
A0A0B4KHH7_DROME
UniprotKB:
Q9VC03,
Q7KS06,
A0A0B4KHH7
UniParc:
UPI000034DFFA,
UPI000007D374,
UPI000034DFFB
EMBL:
BT030750,
AE014297
EnsemblGenome:
FBgn0039254
KO:
dme:Dmel_CG13645
|
| Nucleutide sequences |
EMBL-CDS:
AAF56373.4,
ABV82132.1,
AAN14028.2,
AGB96322.1
Gene_ORFName:
CG13645,
Dmel_CG13645,
Dmel_CG13645,
CG13645,
Dmel_CG13645,
CG13645
EnsemblGenome_TRS:
FBtr0084749,
FBtr0084750,
FBtr0337012
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0084124,
FBpp0084125,
FBpp0307941
RefSeq:
NP_001262942.1,
NP_651315.2,
NP_733064.2,
NP_001356924.1
|
| Others |
UniRef100:
UniRef100_Q9VC03,
UniRef100_Q7KS06
UniRef90:
UniRef90_Q9VC03,
UniRef90_Q7KS06
UniRef50:
UniRef50_Q9VC03,
UniRef50_Q7KS06
UniGene:
Dm.7786
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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