| Type | Description |
|---|---|
| Definition | Nicastrin |
| Date | Results | Publications |
|---|---|---|
| 2017-10-21 12:48:00 | Nct is required for neuronal survival during aging and normal lifespan. | 28495961 |
| 2012-03-03 11:15:00 | Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. | 22086926 |
| 2010-01-21 00:00:00 | Co-expression of Drosophila Pen-2 with Aph-1 and nicastrin increases the formation of Psn fragments as well as gamma-secretase activity | 12660785 |
| 2010-01-21 00:00:00 | Nicastrin is essential to early photoreceptor neuron development | 16145661 |
| 2010-01-21 00:00:00 | the proper assembly of the Aph-1.nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and Aph-1 functions as a stabilizing scaffold in the assembly of this complex | 15644323 |
| Type | IDs |
|---|---|
| Synonymous | CG7012, Dmel\CG7012, Nic, S5A, ST96B, agro, dNct, nct, nic |
| Gene |
UniProtKB-ID:
NICA_DROME,
E1JIV8_DROME,
Q7KS07_DROME,
A0A0B4KHG2_DROME
UniprotKB:
Q9VC27,
E1JIV8,
Q7KS07,
A0A0B4KHG2
UniParc:
UPI000000761D,
UPI0002ADBDD8,
UPI000237F6CA
EMBL:
BT003245,
AE014297,
AF240470
EnsemblGenome:
FBgn0039234
KO:
dme:Dmel_CG7012
|
| Nucleutide sequences |
EMBL-CDS:
AAO25002.1,
AAF56349.2,
AAG11414.1,
ACZ95007.1,
AAS65213.2,
AGB96312.1
Gene_ORFName:
CG7012,
Dmel_CG7012,
CG7012,
CG7012,
Dmel_CG7012,
Dmel_CG7012,
CG7012
EnsemblGenome_TRS:
FBtr0301865,
FBtr0084705,
FBtr0301865,
FBtr0084705,
FBtr0306087,
FBtr0334570
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0084083,
FBpp0291079,
FBpp0291079,
FBpp0084083,
FBpp0297224,
FBpp0306637
RefSeq:
NP_651297.2,
NP_001262932.1,
NP_001163713.1,
NP_996291.2
|
| Others |
UniRef100:
UniRef100_Q9VC27,
UniRef100_A0A0B4KHG2
UniRef90:
UniRef90_Q9VC27
UniRef50:
UniRef50_Q9VC27
UniGene:
Dm.3407
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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