| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 11 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-29 12:45:00 | MLK3 silence induces cervical cancer cell apoptosis via the Notch-1/autophagy network. | 31192472 |
| 2020-07-25 12:10:00 | Study identified that genetic loss/inhibition of a MLK3, increases CD8+ T cell cytotoxicity via inhibition of a prolyl isomerase, Ppia, and nuclear translocation of NFATc1. The MLK3 inhibitor increased the tumor infiltration of cytotoxic T cells in an immune-competent mouse model of breast cancer and increased the cytotoxic T cell population in pan T cells isolated from breast cancer patients with metastatic disease. | 32209667 |
| 2020-07-04 11:14:00 | MLK3 is a newly identified microRNA-520b target that regulates liver cancer cell migration | 32214367 |
| 2020-02-15 12:08:00 | Study revealed that miR-145-5p is downregulated in psoriatic lesional skin and that MLK3 is a direct target of miR-145-5p. Overexpression of miR-145-5p in normal human epidermal keratinocytes (NHEKs) suppressed cell proliferation and secretion of chemokines. In contrast, silencing miR-145-5p promoted NHEK proliferation and increased chemokine secretion. | 30269330 |
| 2019-11-09 11:20:00 | IFN-gamma receptor stimulation requires ULK1-mediated activation of MLK3 and ERK5 | 30459284 |
| Type | IDs |
|---|---|
| Synonymous | MEKK11, MLK-3, MLK3, PTK1, SPRK |
| Gene |
UniProtKB-ID:
M3K11_HUMAN,
A0A024R5E6_HUMAN
UniprotKB:
Q16584,
A0A024R5E6
UniParc:
UPI0000049BF7,
UPI00017A7C82
EMBL:
BC064543,
BC011263,
AP001362,
L32976,
AK316032,
AK299609,
AK222781,
U07747,
CH471076,
AB209655
Ensembl:
ENSG00000173327
KO:
hsa:4296
|
| Nucleutide sequences |
EMBL-CDS:
AAA59859.1,
BAH14403.1,
BAD92892.1,
BAD96501.1,
AAH11263.1,
BAG61538.1,
AAA19647.1,
AAH64543.1,
EAW74417.1,
EAW74418.1
Gene_ORFName:
hCG_23276
Ensembl_TRS:
ENST00000309100,
ENST00000530153
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000433886,
ENSP00000309597
RefSeq:
NP_002410.1
|
| Others |
UniRef100:
UniRef100_Q16584
UniRef90:
UniRef90_Q16584
UniRef50:
UniRef50_Q16584
UniGene:
Hs.502872
CCDS:
CCDS8107.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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