| Type | Description |
|---|---|
| Definition | myeloid leukemia factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:28:00 | CRL4(DCAF8) and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs). | 32703400 |
| 2020-02-22 10:34:00 | the abnormal gene regulation imposed by NPM-MLF1 can be characterized by the enhanced recruitment of NuRD to gene regulatory regions. Thus, different mechanisms would orchestrate the dysregulation of NPM function in NPMc+- versus NPM1-MLF1-associated leukemia. | 31675375 |
| 2017-11-04 11:56:00 | Mutation in HTT causes Huntington's disease (HD); aggregates of mutated HTT cause apoptosis in neurons of HD patients. Data suggest that both MLF1 and MLF2 preferentially interact with mutated N-terminal HTT; MLF1/MLF2 reduce number of neurons (Neuro2A cell line) containing mutant HTT aggregates and subsequent apoptosis. (HTT = Huntingtin protein; MLF = myeloid leukemia factor) | 27840155 |
| 2017-10-07 10:05:00 | The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1/HtrA2-OMI/PARL (HOP) mitochondrial complex to modulate cell survival. | 28137643 |
| 2017-07-15 10:27:00 | These findings suggest that MLF and the associated co-chaperones play a direct role in modulating gene transcription. | 27984043 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
MLF1_HUMAN,
B2RD48_HUMAN,
Q2TLE4_HUMAN,
Q5HYH4_HUMAN,
A0A140VKD2_HUMAN,
A0A0S2Z4U8_HUMAN
UniprotKB:
P58340,
B2RD48,
Q2TLE4,
Q5HYH4,
A0A140VKD2,
A0A0S2Z4U8
UniParc:
UPI000067C9FC,
UPI000011F8D0,
UPI00004C413B,
UPI000013F395,
UPI000006EC1E,
UPI000007134A,
UPI000067C9FB,
UPI00017507C7
EMBL:
CH471052,
AK315402,
AY848700,
BX647666,
HM005672,
AK096889,
L49054,
AK297488,
BC007045,
AY848702,
KU178186,
AC106707,
AC025033,
AK056948,
AY848701
Ensembl:
ENSG00000178053
KO:
hsa:4291
|
| Nucleutide sequences |
EMBL-CDS:
AAX46017.1,
EAW78689.1,
BAG59906.1,
EAW78690.1,
AAA99997.1,
AAH07045.1,
AAX46015.1,
BAC04885.1,
BAB71320.1,
BAG37795.1,
AAX46016.1,
CAI46058.1,
AEE61269.1,
ALQ33644.1,
EAW78685.1
Gene_ORFName:
hCG_16019
Ensembl_TRS:
ENST00000355893,
ENST00000392822,
ENST00000471745,
ENST00000618075,
ENST00000469452,
ENST00000482628,
ENST00000484955,
ENST00000359117,
ENST00000651874,
ENST00000477042,
ENST00000478894
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000417777,
ENSP00000484169,
ENSP00000348157,
ENSP00000418595,
ENSP00000417835,
ENSP00000419637,
ENSP00000498363,
ENSP00000376568,
ENSP00000417141,
ENSP00000420134,
ENSP00000352025
RefSeq:
NP_001365779.1,
NP_001365781.1,
NP_001182361.2,
NP_001365782.1,
NP_001123628.1,
NP_001356713.1,
NP_001356711.1,
NP_001182362.1,
NP_001365784.1,
NP_001123629.1,
NP_001356714.1,
NP_001356712.1,
NP_071888.1,
NP_001365780.1,
NP_001365777.1,
NP_001365775.1,
NP_001365774.1,
NP_001365776.1,
NP_001356710.1,
NP_001182363.1
|
| Others |
UniRef100:
UniRef100_Q2TLE4,
UniRef100_Q5HYH4,
UniRef100_B2RD48,
UniRef100_A0A494C1P6,
UniRef100_P58340
UniRef90:
UniRef90_P58340
UniRef50:
UniRef50_P58340
UniGene:
Hs.85195
CCDS:
CCDS46945.1,
CCDS56286.1,
CCDS56287.1,
CCDS56288.1,
CCDS3182.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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