| Type | Description |
|---|---|
| Definition | BRWD3 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 12:05:00 | study delineates the clinical features associated with BRWD3 null variants and partial gene deletions, and suggests that BRWD3 should be included in the differential diagnosis of patients with an overgrowth-intellectual disability (OGID) phenotype, particularly in male patients with a mild or moderate intellectual disability associated with macrocephaly and/or obesity | 31714006 |
| 2017-05-27 10:20:00 | Our findings identified dBRWD3 as a critical regulator that is uniquely required for ectopic gene expression and aberrant tissue overgrowth caused by PcG mutations. | 27588417 |
| 2015-12-26 10:16:00 | Intellectual disability-associated BRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. | 25666827 |
| 2013-05-25 11:04:00 | BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY | 23479607 |
| 2010-01-21 00:00:00 | In the developing retina, ramshackle (ram) mutant cells have morphological defects including disrupted apical junctions, disorganized actin cytoskeletons and mislocalized nuclei. | 16904300 |
| Type | IDs |
|---|---|
| Synonymous | Brwd3, CG18670, CG31132, CG6400, Dmel\CG31132, anon-WO0118547.520, anon-WO0118547.620, brwd3, dBRWD3, l(3)05842, l(3)s5349, psg13, ram |
| Gene |
UniProtKB-ID:
Q9VC96_DROME
UniprotKB:
Q9VC96
UniParc:
UPI0000083039
EMBL:
AE014297
EnsemblGenome:
FBgn0011785
KO:
dme:Dmel_CG31132
|
| Nucleutide sequences |
EMBL-CDS:
AAF56278.2
Gene_ORFName:
Dmel_CG31132,
CG31132
EnsemblGenome_TRS:
FBtr0084604
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0083988
RefSeq:
NP_732982.1
|
| Others |
UniRef100:
UniRef100_Q9VC96
UniRef90:
UniRef90_Q9VC96
UniRef50:
UniRef50_Q9VC96
UniGene:
Dm.5099
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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