| Type | Description |
|---|---|
| Definition | spastin |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 12:37:00 | A ~3.2 A resolution cryo-EM structure of the D. melanogaster spastin hexamer with a polyglutamate peptide bound in its central pore reveals how concurrent nucleotide and substrate binding organizes the conserved spastin pore loops into an ordered network that is allosterically coupled to oligomerization. 2 electropositive loops arranged in a double-helical staircase coordinate the substrate sidechains. | 31285604 |
| 2016-03-26 10:38:00 | targeting sequence directs spastin to the surface of lipid droplets. Depletion of the homologous spastin proteins in both flies and worms affects lipid droplet number and triacylglycerol content. | 25875445 |
| 2013-06-29 12:03:00 | analysis of spastin's microtubule-binding properties and comparison with katanin | 23272056 |
| 2013-05-11 12:40:00 | The spastin is a key regulator of axon regeneration, and initiation of regeneration is extremely sensitive to the spastin copy number. | 23122959 |
| 2011-05-14 10:46:00 | Dendritic growth is regulated by Kruppel-like factor dendritic arbor reduction protein 1 (Dar1) suppressing the expression of microtubule-severing protein spastin. | 21368042 |
| Type | IDs |
|---|---|
| Synonymous | CG5977, D-spastin, Dmel\CG5977, Dspastin, Spas, Spastin |
| Gene |
UniProtKB-ID:
SPAST_DROME,
A0A0B4LHJ5_DROME,
A0A126GV13_DROME,
A0A126GV10_DROME
UniprotKB:
Q8I0P1,
A0A0B4LHJ5,
A0A126GV13,
A0A126GV10
UniParc:
UPI0000007614,
UPI0006AD098B,
UPI0000080B09,
UPI0002943E31
EMBL:
BT001351,
BT044258,
AY069522,
BT001254,
AE014297
EnsemblGenome:
FBgn0039141
KO:
dme:Dmel_CG5977
|
| Nucleutide sequences |
EMBL-CDS:
AAL39667.1,
AAN13975.2,
ACH92323.1,
AAN71106.1,
AAF56223.3,
AAN71010.1,
AHN57493.1,
AGB96276.1,
ALI30635.1,
ALI30634.1
Gene_ORFName:
CG5977,
CG5977,
Dmel_CG5977,
CG5977,
Dmel_CG5977,
CG5977,
Dmel_CG5977
EnsemblGenome_TRS:
FBtr0084534,
FBtr0084533,
FBtr0346099,
FBtr0321260,
FBtr0445311,
FBtr0445310
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0083918,
FBpp0083919,
FBpp0311932,
FBpp0302812,
FBpp0401488,
FBpp0401487
RefSeq:
NP_001303437.1,
NP_732941.2,
NP_001262896.1,
NP_001287494.1,
NP_001303438.1,
NP_651206.3
|
| Others |
UniRef100:
UniRef100_Q8I0P1,
UniRef100_A0A0B4LHJ5
UniRef90:
UniRef90_B3M301,
UniRef90_Q8I0P1
UniRef50:
UniRef50_Q8I0P1
UniGene:
Dm.7035
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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