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4248 MGAT3

4248

MGAT3

mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

protein-coding

Homo sapiens

基因描述

Type Description
Definition mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

研究结论

Date Results Publications
2020-05-23 12:40:00 Study found that N-Acetylglucosaminyltransferase III (GnT-III) is expressed in trophoblasts during normal human pregnancy and is involved in regulating trophoblast function. 29642803
2019-10-19 10:25:00 The expression of GnT-III in placenta suggests a role for GnT-III in the regulation of tropho- blast behavior. And decreased expression of GnT-III is associated with oxidative stress in preeclamptic pla- centas and, thus, may be involved in the pathogenesis of preeclampsia. 29466889
2019-05-25 10:10:00 Results strongly indicate that the MGAT3 and BACH2 genes play an important role in IBD pathogenesis and suggest a possible disease pathway mediated by the pro-inflammatory properties of IgG antibodies acquired by alterations in Fc glycosylation. 29991969
2018-02-10 11:14:00 Novel insights into the epigenetic regulation of MGAT3/bisecting GlcNAc and demonstrate the importance of N-glycosylation in cancer progression. 27429195
2017-10-21 11:52:00 Data suggest that GNT-III expression regulates levels/activation of the heavily glycosylated Notch receptor involved in normal and malignant cell development; suppression of GNT-III in epithelial ovarian carcinoma cell lines results in down-regulation of Notch signaling that is more potent than pharmacologic blockage of Notch activation. 28842505

名称对应

Type IDs
Synonymous GNT-III, GNT3
Gene
UniProtKB-ID: MGAT3_HUMAN
UniprotKB: Q09327
UniParc: UPI00003765B6
EMBL: BC113718, D13789, AL022312, CR456519, BC113383, BC075026, BC075025
Ensembl: ENSG00000128268
KO: hsa:4248
Nucleutide sequences
EMBL-CDS: AAH75025.1, AAI13384.1, CAG30405.1, BAA02937.1, AAI13719.1, AAH75026.1
Ensembl_TRS: ENST00000341184
Protein sequencees
Ensembl_PRO: ENSP00000345270
RefSeq: NP_001091740.1, NP_002400.3
Others
UniRef100: UniRef100_Q09327
UniRef90: UniRef90_Q09327
UniRef50: UniRef50_Q10470
UniGene: Hs.276808
CCDS: CCDS13994.2

全选

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