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4245 MGAT1

4245

MGAT1

mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

protein-coding

Homo sapiens

基因描述

Type Description
Definition mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

研究结论

Date Results Publications
2021-02-20 13:36:00 Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis. 32763972
2020-07-25 11:39:00 MGAT1 promotes complex N-glycosylation of glucose transporter 1 (Glut1) and increases Glut1 protein levels. In summary, our findings indicate that MGAT1 is highly expressed in glioblastoma and promotes glioma cells at least partly through upregulation of Glut1 protein. 31494931
2019-09-14 10:52:00 MGAT1 activity may play a role in regulating basal adipocyte FFA retention 29853530
2018-08-11 11:34:00 In this study we showed that the activation of Wnt/beta-catenin pathway culminates in the upregulation of MGAT1 enzyme both at transcriptional and post-transcriptional levels. We also showed that overexpression of the beta-catenin gene (CTNNB1) increased the promoter activity of MGAT1. 29310626
2018-01-13 10:03:00 The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population. 27871764

名称对应

Type IDs
Synonymous GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, GnTI, MGAT
Gene
UniProtKB-ID: MGAT1_HUMAN
UniprotKB: P26572
UniParc: UPI000013CDF1
EMBL: CH471165, AK092256, AK290769, AK094130, M55621, AC022413, M61829, CR456861, BC003575
Ensembl: ENSG00000131446
KO: hsa:4245
Nucleutide sequences
EMBL-CDS: EAW53742.1, BAG52510.1, EAW53740.1, EAW53739.1, BAF83458.1, CAG33142.1, AAA75523.1, AAH03575.1, EAW53743.1, BAG52821.1, AAA52563.1, EAW53741.1, EAW53744.1
Ensembl_TRS: ENST00000393340, ENST00000333055, ENST00000307826, ENST00000446023, ENST00000427865
Protein sequencees
Ensembl_PRO: ENSP00000377010, ENSP00000402838, ENSP00000332073, ENSP00000311888, ENSP00000404718
RefSeq: NP_001351320.1, NP_001351315.1, NP_001351322.1, NP_001108092.1, NP_001351313.1, NP_001351318.1, NP_001351316.1, NP_001351323.1, NP_001108090.1, NP_002397.2, NP_001351314.1, NP_001351308.1, NP_001351317.1, NP_001351306.1, NP_001351324.1, NP_001108091.1, NP_001108089.1, NP_001351310.1, NP_001351321.1, NP_001351312.1, NP_001351311.1, NP_001351309.1, NP_001351319.1
Others
UniRef100: UniRef100_P26572
UniRef90: UniRef90_P26572
UniRef50: UniRef50_P26572
UniGene: Hs.519818
CCDS: CCDS4458.1

全选

研究热度
发表文献
研究结论
热点单位
排名 科研单位 文献
1

Albert Einstein College of Medicine

4
2

Research Institute

3
3

Helix Research Institute

2
4

Uppsala University

2
5

Ontario Cancer Institute

2
热点人员
排名 研究人员 文献
1

Sumio Sugano

5
2

Yutaka Suzuki

5
3

Riu Yamashita

3
4

Kenta Nakai

3
5

Keiichi Nagai

3
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