| Type | Description |
|---|---|
| Definition | Leucine-rich repeat kinase |
| Date | Results | Publications |
|---|---|---|
| 2018-09-01 12:06:00 | aberrant function of LRRK2 may lead to destabilization of neural circuits. | 27432119 |
| 2017-08-12 10:45:00 | Data support the view that LRRK2/Lrrk is a gene/protein involved in oxidative stress-signaling leading to neurodegenerative process and loss of DAergic neurons and that reduced/suppressed LRRK2 expression might delay or prevent motor symptoms and/or frank Parkinsonism in individuals at risk to suffer autosomal dominant Parkinsonism. | 28041945 |
| 2017-07-29 12:39:00 | EndophilinA-induced macroautophagy is activated when the kinase LRRK2 phosphorylates the EndophilinA-BAR domain and is blocked in animals where EndophilinA cannot be phosphorylated. Functionally, deregulation of the EndophilinA phosphorylation state accelerates activity-induced neurodegeneration. | 27720484 |
| 2017-07-29 11:25:00 | Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3beta activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism. | 26931464 |
| 2017-05-20 12:11:00 | Our results suggest LRRK2 may be involved in a wide variety of cellular processes and the results from this screen provide an important genetic resource for further evaluation of LRRK2 function | 28158614 |
| Type | IDs |
|---|---|
| Synonymous | CG5483, CT17358, Dmel\CG5483, LRRK, LRRK2, dLRRK, dLRRK2, dLrrk, lrrk |
| Gene |
UniProtKB-ID:
Q9VDJ9_DROME,
A0A0B4KH16_DROME,
A0A0B4KHT3_DROME
UniprotKB:
Q9VDJ9,
A0A0B4KH16,
A0A0B4KHT3
UniParc:
UPI0002ADBD6A,
UPI0000DB272D,
UPI0002ADBE14
EMBL:
DQ494533,
AE014297
EnsemblGenome:
FBgn0038816
KO:
dme:Dmel_CG5483
|
| Nucleutide sequences |
EMBL-CDS:
AAF55793.3,
ABF29833.1,
AGB96151.1,
AGB96152.1
Gene_ORFName:
Dmel_CG5483,
CG5483,
CG5483,
Dmel_CG5483,
CG5483,
Dmel_CG5483
EnsemblGenome_TRS:
FBtr0112788,
FBtr0334640,
FBtr0334641
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0111700,
FBpp0306702,
FBpp0306703
RefSeq:
NP_001262771.1,
NP_001097847.1,
NP_001262772.1
|
| Others |
UniRef100:
UniRef100_A0A0B4KH16,
UniRef100_Q9VDJ9,
UniRef100_A0A0B4KHT3
UniRef90:
UniRef90_Q9VDJ9
UniRef50:
UniRef50_Q9VDJ9
UniGene:
Dm.24081
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员