| Type | Description |
|---|---|
| Definition | meprin A subunit alpha |
| Date | Results | Publications |
|---|---|---|
| 2018-03-03 12:13:00 | Mep1A is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A expression is regulated by Reptin, and Mep1A mediates Reptin-induced migration. | 27999200 |
| 2018-02-10 12:08:00 | In this review we report on recent findings that summarize the complex molecular regulation of meprins, particular folding, activation and shedding. Dysregulation of meprin alpha and meprin beta is often associated with pathological conditions such as neurodegeneration, inflammatory bowel disease and fibrosis | 28502593 |
| 2017-10-21 10:43:00 | Results showed that MEP1A expression was elevated in colorectal cancer (CRC) tissues at both the mRNA and protein levels, and provided evidence for its functionally crucial role in CRC carcinogenesis as tumor proliferation and invasion. | 27378469 |
| 2014-06-28 10:24:00 | Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin metabolism in overweight/obese central European women with polycystic ovary syndrome. | 24388959 |
| 2014-05-17 10:15:00 | Meprin metalloproteases A and B inactivate interleukin 6 | 24474695 |
| Type | IDs |
|---|---|
| Synonymous | PPHA |
| Gene |
UniProtKB-ID:
MEP1A_HUMAN,
B7ZL91_HUMAN
UniprotKB:
Q16819,
B7ZL91
UniParc:
UPI000189A7FD,
UPI000006E4E9
EMBL:
CH471081,
AK290282,
AK315840,
AF478685,
M82962,
BC131714,
BC143651,
AK315246,
AL161618
Ensembl:
ENSG00000112818
KO:
hsa:4224
|
| Nucleutide sequences |
EMBL-CDS:
AAA21338.1,
EAX04306.1,
BAF82971.1,
AAL85339.1,
BAG37669.1,
AAI31715.1,
BAF98731.1,
AAI43652.1
Ensembl_TRS:
ENST00000230588,
ENST00000611727
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000230588,
ENSP00000480465
RefSeq:
XP_011512931.1,
NP_005579.2,
XP_011512930.1
|
| Others |
UniRef100:
UniRef100_Q16819,
UniRef100_B7ZL91
UniRef90:
UniRef90_Q16819
UniRef50:
UniRef50_P28825
UniGene:
Hs.179704
CCDS:
CCDS4918.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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