| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 12:58:00 | The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress. | 31623019 |
| 2020-07-11 10:48:00 | these results suggest that in resting platelets ASK1 is bound to CIB1 at low Ca2+ concentrations. Agonist-induced platelet activation causes an increase in intracellular Ca2+ concentration that leads to the dissociation of CIB1 from ASK1, allowing for proper dimerization through ASK1 N-terminal coiled-coil (NCC) domains. | 31530712 |
| 2020-06-13 10:47:00 | The discovery of novel ASK1 inhibitors would have a wide range of applications in medical science. In-silico techniques have been successfully used in the design of some novel ASK1 inhibitors. The use of machine learning-based approaches in combination with structure-based virtual screening (SBVS) and ligand-based virtual screening (LBVS) will be helpful toward the development of potent ASK1 inhibitors | 31593641 |
| 2020-05-30 12:15:00 | This review summarized experimental evidences regarding the association between ASK1 and the pathogenesis of various diseases. [review] | 30617854 |
| 2020-04-18 10:37:00 | Herein, the authors identify apoptosis signal-regulating kinase 1 (ASK1) as a suppressor of non-alcoholic steatohepatitis and fibrosis formation. | 31595673 |
| Type | IDs |
|---|---|
| Synonymous | ASK1, MAPKKK5, MEKK5 |
| Gene |
UniProtKB-ID:
M3K5_HUMAN
UniprotKB:
Q99683
UniParc:
UPI00017A6EEF,
UPI000012EAD5
EMBL:
AL121933,
AK294507,
BC054503,
AL024508,
BC088829,
U67156,
D84476
Ensembl:
ENSG00000197442
KO:
hsa:4217
|
| Nucleutide sequences |
EMBL-CDS:
AAH54503.1,
AAC50894.1,
BAA12684.2,
AAH88829.1,
BAG57723.1
Ensembl_TRS:
ENST00000359015
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000351908
RefSeq:
XP_016866366.1,
NP_005914.1,
XP_016866359.1,
XP_016866361.1,
XP_016866360.1,
XP_016866364.1,
XP_016866362.1,
XP_011534141.2,
XP_016866363.1,
XP_016866365.1
|
| Others |
UniRef100:
UniRef100_Q99683
UniRef90:
UniRef90_Q99683
UniRef50:
UniRef50_Q99683
UniGene:
Hs.186486
CCDS:
CCDS5179.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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