| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:09:00 | A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. | 31915244 |
| 2020-02-08 10:41:00 | These mutations increase the binding of the RHOA, MAP3K4 and FRAT1 proteins and generally decrease the binding of RAC1. Thus, pathologies in MAP3K1 disrupt the balance between the pro-kinase activities of the RHOA and MAP3K4 binding partners and the inhibitory activity of RAC1. | 30608580 |
| 2019-06-01 10:45:00 | MAP3K4 was up-regulated and its expression was inversely correlated with collagen expression in the osteoblasts from older donors. | 30217450 |
| 2016-08-20 10:06:00 | IL-21 expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma | 26802931 |
| 2015-02-07 12:12:00 | Mutations in genes such as AKT2, CCNA1, MAP3K4, and TGFBR1, were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors. | 25173755 |
| Type | IDs |
|---|---|
| Synonymous | MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412 |
| Gene |
UniProtKB-ID:
M3K4_HUMAN,
Q9P1M2_HUMAN
UniprotKB:
Q9Y6R4,
Q9P1M2
UniParc:
UPI000049E061,
UPI000006F817,
UPI00004574E1
EMBL:
AF002715,
AL109942,
BC136276,
D86968,
BC146770,
AL591045,
BC143735,
AF116604,
CH471051,
AL139393,
AL596452
Ensembl:
ENSG00000085511
KO:
hsa:4216
|
| Nucleutide sequences |
EMBL-CDS:
AAI43736.1,
EAW47587.1,
BAA13204.2,
AAB68804.1,
AAI36277.1,
AAI46771.1,
AAF71029.1
Ensembl_TRS:
ENST00000366919,
ENST00000392142
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000375986,
ENSP00000355886
RefSeq:
NP_006715.3,
NP_005913.3,
NP_001278887.1,
XP_016866358.1,
NP_001350511.2,
NP_001288001.2
|
| Others |
UniRef100:
UniRef100_Q9P1M2,
UniRef100_Q9Y6R4
UniRef90:
UniRef90_Q9Y6R4,
UniRef90_A0A2K6LSD8
UniRef50:
UniRef50_A0A2K6LSD8,
UniRef50_Q9Y6R4
UniGene:
Hs.390428
CCDS:
CCDS34565.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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