| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 13:56:00 | Overexpression of MAP3K3 promotes tumour growth through activation of the NF-kappaB signalling pathway in ovarian carcinoma. | 31182739 |
| 2020-02-22 12:10:00 | This study suggests that expression of miR-194 is down-regulated in nasopharyngeal carcinoma, and that miR-194 can directly target MAP3K3 to regulate tumor progression. Given the pivotal involvement of MAP3K3 in nasopharyngeal carcinoma development, targeting miR-194 may be a novel strategy for the treatment of nasopharyngeal carcinoma. | 30652073 |
| 2019-08-03 10:18:00 | MEKK3 overexpression prevented the inhibitory effects of miR9 on the viability, migration and invasion of PC cells. | 30896820 |
| 2019-05-25 12:06:00 | the data revealed the novel role and target of miR505 in NSCLC cells, which may provide novel insights regarding its role in the carcinogenesis of NSCLC and its potential values for clinical applications. | 30628663 |
| 2019-03-16 10:18:00 | Its downstream target MAP3K3 could be a potential therapeutic target for NSCLC. | 29528232 |
| Type | IDs |
|---|---|
| Synonymous | MAPKKK3, MEKK3 |
| Gene |
UniProtKB-ID:
M3K3_HUMAN,
Q96HN9_HUMAN,
J3KRN4_HUMAN
UniprotKB:
Q99759,
Q96HN9,
J3KRN4
UniParc:
UPI000268B35E,
UPI0000074003,
UPI0000072ABE,
UPI00002011CC
EMBL:
AL834303,
AK315305,
BC093672,
U78876,
BC093674,
AC046185,
BC090859,
CH471109,
BC008336
Ensembl:
ENSG00000198909
KO:
hsa:4215
|
| Nucleutide sequences |
EMBL-CDS:
AAH93674.1,
EAW94297.1,
AAB41729.1,
AAH93672.1,
AAH90859.1,
EAW94298.1,
BAG37709.1,
EAW94299.1,
CAD38973.1,
AAH08336.1
Ensembl_TRS:
ENST00000361733,
ENST00000361357,
ENST00000579585,
ENST00000577395
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000461988,
ENSP00000354927,
ENSP00000354485,
ENSP00000462086
RefSeq:
XP_005257435.1,
NP_001317360.1,
NP_976226.1,
NP_002392.2,
NP_001350697.1
|
| Others |
UniRef100:
UniRef100_J3KRN4,
UniRef100_Q99759
UniRef90:
UniRef90_Q99759,
UniRef90_Q61084
UniRef50:
UniRef50_Q99759
UniGene:
Hs.29282
CCDS:
CCDS32702.1,
CCDS32701.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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