| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:21:00 | Nonsense-associated altered splicing of MAP3K1 in two siblings with 46,XY disorders of sex development. | 33060765 |
| 2020-10-24 14:11:00 | A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. | 32817551 |
| 2020-03-10 10:49:00 | miR-101 expression and RISC binding is increased after cyclosporine treatment in kidney cells; targets and reduces expression of MAP3K1 in vitro | 28925592 |
| 2020-02-08 10:41:00 | These mutations increase the binding of the RHOA, MAP3K4 and FRAT1 proteins and generally decrease the binding of RAC1. Thus, pathologies in MAP3K1 disrupt the balance between the pro-kinase activities of the RHOA and MAP3K4 binding partners and the inhibitory activity of RAC1. | 30608580 |
| 2019-04-06 12:47:00 | Of note, the enforced expression of MEKK1 or the exposure of medulloblastoma cells to the MEKK1 activator, Nocodazole, resulted in a marked inhibitory effect on GLI1 activity and tumor cell proliferation and viability. Taken together, the results of this study shed light on a novel regulatory mechanism of HH signaling, with potentially relevant implications in cancer therapy. | 30483764 |
| Type | IDs |
|---|---|
| Synonymous | MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6 |
| Gene |
UniProtKB-ID:
M3K1_HUMAN
UniprotKB:
Q13233
UniParc:
UPI000015153B
EMBL:
AF042838,
U29671,
AC008937
Ensembl:
ENSG00000095015
KO:
hsa:4214
|
| Nucleutide sequences |
EMBL-CDS:
AAC97073.1,
AAB05828.1
Ensembl_TRS:
ENST00000399503
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000382423
RefSeq:
NP_005912.1,
XP_016864973.1,
XP_016864974.1
|
| Others |
UniRef100:
UniRef100_Q13233
UniRef90:
UniRef90_Q13233
UniRef50:
UniRef50_Q13233
UniGene:
Hs.653654
CCDS:
CCDS43318.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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