| Type | Description |
|---|---|
| Definition | Ataxin-2 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-01 12:47:00 | Loss of CrebA also partially suppresses mHtt effects on behavior and cell loss and restoration of CrebA can suppress Atx2 effects. Our results indicate a prominent role of Atx2 in mediating mHtt pathology, specifically via its regulation of CrebA, defining a novel molecular pathway in Huntington's disease pathogenesis. | 31593562 |
| 2020-01-11 10:41:00 | Study shows that the Drosophila ortholog of human ATXN2, dAtx2, is a potent enhancer of CREST toxicity. Downregulation of dAtx2 in flies overexpressing CREST in retinal ganglion cells was sufficient to largely rescue the severe amyotrophic lateral sclerosis degenerative phenotype induced by mutant human CREST in transgenic Drosophila. | 31390360 |
| 2019-08-03 13:08:00 | Atx2 intrinsically disordered regions (IDRs), which are capable of mediating liquid-liquid phase transitions in vitro, are essential for efficient formation of neuronal mRNP assemblies in vivo. DeltaIDR mutants that lack neuronal RNP granules show normal development, survival, and fertility. However, they show defects in long-term memory formation/consolidation and in C9ORF72 dipeptide repeat or FUS-induced neurodegene... | 29772202 |
| 2017-09-09 14:08:00 | LSM12 and ME31B/DDX6 define distinct modes of posttranscriptional regulation by ATAXIN-2 protein complex in drosophila circadian pacemaker neurons. | 28388438 |
| 2014-03-15 10:04:00 | FMRP and Ataxin-2 have roles in long-term olfactory habituation and neuronal translational control | 24344294 |
| Type | IDs |
|---|---|
| Synonymous | ATX2, Atx-2, Atxain-2, BEST:GH27029, CG43368, CG5166, CG5166a, Datx2, Dmel\CG5166, GH27029, SCA2, Sca2, anon-EST:fe2E1, anon-WO0118547.351, anon-WO0140519.1, atx-2, atx2, dAtx2, dSCA2, l(3)06490 |
| Gene |
UniProtKB-ID:
ATX2_DROME,
A0A0B4LH64_DROME
UniprotKB:
Q8SWR8,
A0A0B4LH64
UniParc:
UPI00000075A3,
UPI0000083C8B,
UPI00000838A9
EMBL:
AE014297,
BT001340,
BT001272,
AY069494,
AY095516,
AY058253
EnsemblGenome:
FBgn0041188
KO:
dme:Dmel_CG5166
|
| Nucleutide sequences |
EMBL-CDS:
AAN13663.1,
AAN13664.2,
AAM12250.1,
AAN71028.1,
AAF55196.2,
AAL39639.1,
AAN71095.1,
AAL13482.1,
AHN57338.1
Gene_ORFName:
CG5166,
Dmel_CG5166,
CG5166
EnsemblGenome_TRS:
FBtr0083100,
FBtr0083099,
FBtr0344377,
FBtr0083101,
FBtr0344377,
FBtr0083100
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0082555,
FBpp0082557,
FBpp0082556,
FBpp0310750,
FBpp0082556,
FBpp0310750
RefSeq:
NP_732033.1,
NP_650466.2,
NP_001287339.1,
NP_732034.2
|
| Others |
UniRef100:
UniRef100_Q8SWR8
UniRef90:
UniRef90_Q8SWR8
UniRef50:
UniRef50_Q8SWR8
UniGene:
Dm.1489
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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