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41602 CtBP

41602

CtBP

C-terminal Binding Protein

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition C-terminal Binding Protein

研究结论

Date Results Publications
2021-04-03 13:38:00 Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi. 32122936
2020-05-02 10:14:00 Data show separable and cell-type-specific functions of Groucho (Gro) and C-terminal binding protein (CtBP) in a Notch signaling cascade involved lateral inhibition process. 30982741
2019-08-10 12:28:00 Thus, CtBP stabilizes cell fates following damage by opposing the destabilizing effects of the JNK/AP-1 and pathways. 29372681
2018-02-17 10:56:00 Here we provide evidence that although wild type CtBP negatively and dominantly influences Dpp signaling in fly presumptive wings, mutant CtBP unable to form dimer does not, indicating that dimerization is required for the repression role of CtBP in Dpp signaling in vivo. 29225171
2017-06-24 12:27:00 We found that TCF7L1 recruits the C-terminal binding protein (CtBP) and histone deacetylase 1 (HDAC1) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1, TCF7L2 and beta-catenin occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs. 28450117

名称对应

Type IDs
Synonymous 0256/16, 256/16, BcDNA:GH07572, CG7583, CTBP, Dm-CtBP, Dmel\CG7583, EP(3)3528, G9, RE01030, RE61183, ctbp, dCtBP, l(3)03463, l(3)03464, l(3)87DE, l(3)87De, l(3)G9
Gene
UniProtKB-ID: CTBP_DROME, A4V2S3_DROME, A0A0B4KGZ7_DROME, A0A0B4KFT4_DROME, A0A0B4KHB2_DROME, A0A0B4KGG9_DROME, A0A0B4KFX5_DROME
UniprotKB: O46036, A4V2S3, A0A0B4KGZ7, A0A0B4KFT4, A0A0B4KHB2, A0A0B4KGG9, A0A0B4KFX5
UniParc: UPI000016B566, UPI0002ADBDA3, UPI0002ADBCF7, UPI0002ADBD2F, UPI0000000F78, UPI000066E781, UPI0000453676
EMBL: AE014297, AY060646, AJ224690, AB011840, AY069170
EnsemblGenome: FBgn0020496
KO: dme:Dmel_CG7583
Nucleutide sequences
EMBL-CDS: BAA25287.1, AAL39315.1, AAX52947.1, AAF54891.1, CAA12074.1, AAL28194.2, AAN14339.1, AAF54892.1, AAN14340.1, AGB95904.1, AGB95906.1, AGB95903.1, AGB95902.1, AGB95905.1
Gene_ORFName: CG7583, CG7583, Dmel_CG7583, Dmel_CG7583, CG7583, Dmel_CG7583, CG7583, Dmel_CG7583, CG7583, Dmel_CG7583, CG7583, CG7583, Dmel_CG7583
EnsemblGenome_TRS: FBtr0100161, FBtr0082700, FBtr0082702, FBtr0082699, FBtr0082701, FBtr0082699, FBtr0082702, FBtr0082701, FBtr0082700, FBtr0334515, FBtr0334517, FBtr0334514, FBtr0334513, FBtr0334516
Protein sequencees
EnsemblGenome_PRO: FBpp0082169, FBpp0082167, FBpp0082168, FBpp0099514, FBpp0082170, FBpp0082168, FBpp0082167, FBpp0082170, FBpp0082169, FBpp0306582, FBpp0306584, FBpp0306581, FBpp0306580, FBpp0306583
RefSeq: NP_731764.1, NP_731763.1, NP_001262521.1, NP_001014617.1, NP_001262523.1, NP_001262524.1, NP_001262520.1, NP_731762.1, NP_524336.2, NP_001262522.1
Others
UniRef100: UniRef100_A0A0B4KGZ7, UniRef100_O46036, UniRef100_A0A0B4KFT4, UniRef100_A0A0B4KFX5, UniRef100_A4V2S3, UniRef100_A0A0B4KGG9, UniRef100_A0A0B4KHB2
UniRef90: UniRef90_O46036, UniRef90_A4V2S3
UniRef50: UniRef50_Q13363
UniGene: Dm.2246

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