| Type | Description |
|---|---|
| Definition | melanocortin 2 receptor |
| Date | Results | Publications |
|---|---|---|
| 2019-11-16 11:09:00 | Results indicate that substitution of the amino acid residue leucine to isoleucine in 112 (L112I) of one of the transmembrane domains in the MC2R changes from both DPhe-ACTH1-17 and ACTH1-15 from no activity to agonists. Also, mutation L112I switches alpha-MSH from no activity to agonist, suggesting that this residue plays a key role at MC2R for ligand ACTH or alpha-MSH selectivity. | 30553806 |
| 2017-08-05 12:12:00 | Results show regulation of melanocortin receptors MC2R, MC3R and MC4R gene expressions in CD8(+) cytotoxic T-lymphocytes and CD19(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha) inhibitor adalimumab. | 28426141 |
| 2017-07-15 10:33:00 | Four rare missense variants were identified (ACTBL2 rs73757391 (5q11.2), BTD rs200337373 (3p25.1), KRT13 rs150321809 (17q21.2) and MC2R rs104894658 (18p11.21)), but only MC2R rs104894668 had a large effect size (OR = 9.66). | 27378695 |
| 2016-07-30 11:18:00 | melanocortin receptors MC2R, MC3R and MC5R are most abundantly expressed in glandular epithelium of the endometrium | 26223677 |
| 2016-04-23 10:43:00 | MC2R and MC1R signals are consecutively required for the regulation of EPO signal transduction in erythroblast differentiation, and MC5R signal transduction is required to induce enucleation. | 25860801 |
| Type | IDs |
|---|---|
| Synonymous | ACTHR |
| Gene |
UniProtKB-ID:
ACTHR_HUMAN
UniprotKB:
Q01718
UniParc:
UPI00000503E5
EMBL:
AK289381,
BC104169,
X65633,
BC104170,
AB065915,
BC094710,
AY225229,
BC069074,
CH471113,
AK315319
Ensembl:
ENSG00000185231
KO:
hsa:4158
|
| Nucleutide sequences |
EMBL-CDS:
AAI04171.1,
BAG37722.1,
CAA46587.1,
BAF82070.1,
BAC06130.1,
EAX01503.1,
AAH94710.1,
AAI04170.1,
AAH69074.1,
AAO67714.1
Ensembl_TRS:
ENST00000327606
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000333821
RefSeq:
XP_016881270.1,
NP_000520.1,
NP_001278840.1
|
| Others |
UniRef100:
UniRef100_Q01718
UniRef90:
UniRef90_Q01718
UniRef50:
UniRef50_Q01718
UniGene:
Hs.248144
CCDS:
CCDS11869.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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