| Type | Description |
|---|---|
| Definition | microtubule associated serine/threonine kinase like L homeolog |
| Date | Results | Publications |
|---|---|---|
| 2017-07-08 11:46:00 | Data suggest Greatwall kinase (Gwl) associates with protein phosphatase 1 (PP1), particularly PP1gamma subunit, which mediates dephosphorylation of Gwl Ser-883; consistent with mitotic activation of Gwl, its association with PP1 is disrupted in mitotic cells; subunits PPP1R3B and PPP1R13L associate with Gwl; thus, PPP1R3B appears to act as cell cycle regulator in oocytes that functions by governing Gwl dephosphorylation. | 28446604 |
| 2016-12-31 11:51:00 | Full dephosphorylation of Gwl results in complete inactivation of Arpp19 and ENSA, and dephosphorylation of mitotic substrates. this feed-back loop irreversibly induces mitotic exit. | 26906418 |
| 2016-08-20 11:43:00 | study provides evidence that PP1 targets the auto-phosphorylation site of Gwl, resulting in efficient Gwl inactivation; this step is necessary to facilitate subsequent complete dephosphorylation of Gwl by PP2A-B55 | 26396231 |
| 2015-09-26 13:19:00 | we showed that the Gwl nuclear localization is indispensable for the biochemical function of Gwl in promoting mitotic entry. | 25483093 |
| 2014-04-26 10:05:00 | PP2A-B55delta, Greatwall and are not only required for entry into meiotic divisions, but are also pivotal effectors within the Cdk1 auto-regulatory loop responsible for its independence with respect to the control. | 23781026 |
| Type | IDs |
|---|---|
| Synonymous | GW, GWL, MAST-L, greatwall, mastl, thc2 |
| Gene |
UniProtKB-ID:
GWL_XENLA
UniprotKB:
Q6NTJ3
UniParc:
UPI0000352BF3
EMBL:
AY644649,
BC068968
KO:
xla:414585
|
| Nucleutide sequences |
EMBL-CDS:
AAH68968.1,
AAT65679.1
|
| Protein sequencees |
RefSeq:
NP_001084629.1
|
| Others |
UniRef100:
UniRef100_Q6NTJ3
UniRef90:
UniRef90_Q6NTJ3
UniRef50:
UniRef50_Q6NTJ3
UniGene:
Xl.3201
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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