| Type | Description |
|---|---|
| Definition | defensin beta 103A |
| Date | Results | Publications |
|---|---|---|
| 2019-11-16 12:33:00 | In aged skin the relative paucity of Langerhans cells not only results in diminished immunosurveillance, but could also reduce the epidermal pool of HBD3, potentially contributing to impaired cutaneous immunity to microbes and reduced efficacy of tumor cell lysis. | 29758092 |
| 2019-04-06 11:03:00 | Results from study in human monocytic cell line THP-1 and murine macrophage-like cell line RAW264.7 demonstrate a novel immune defense activity of BD2 and BD3, which promotes clearance of Pseudomonas aeruginosa by inhibiting macrophage autophagy through down-regulation of EGR1 and c-FOS. | 29487594 |
| 2017-07-15 10:33:00 | this study shows that hBD3 amplifies the response to bacterial DNA in both mouse and human immune cells in a TLR9-dependent manner | 28102569 |
| 2016-05-14 12:07:00 | the role of DEFB103 gene copy number variation (CNV) in ankylosing spondylitis (AS) susceptibility, was investigated. | 26224324 |
| 2015-09-12 11:36:00 | It may be concluded hepatitis B virus up-regulates HBD-3 and A3G expression in vivo and in vitro in placental trophoblast and lack of this up-regulation is possibly associated with intrauterine transmission of hepatitis B. | 25196417 |
| Type | IDs |
|---|---|
| Synonymous | BD-3, DEFB-3, DEFB103, DEFB3, HBD3, HBP-3, HBP3 |
| Gene |
UniProtKB-ID:
D103A_HUMAN
UniprotKB:
P81534
UniParc:
UPI0000033C6C
EMBL:
AF295370,
AF516673,
AF217245,
AB037972,
AJ237673,
AF301470
Ensembl:
ENSG00000285376,
ENSG00000284978,
ENSG00000273641,
ENSG00000176797,
ENSG00000177243
KO:
hsa:55894,
hsa:414325
|
| Nucleutide sequences |
EMBL-CDS:
AAF73853.1,
BAB40572.1,
AAG22030.1,
CAC03097.1,
AAM62424.1,
AAG02237.1
Ensembl_TRS:
ENST00000642635,
ENST00000318124,
ENST00000646344,
ENST00000613448,
ENST00000314357,
ENST00000646258
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000320951,
ENSP00000480773,
ENSP00000324633,
ENSP00000493640,
ENSP00000495040,
ENSP00000493616
RefSeq:
NP_001075020.1
|
| Others |
UniRef100:
UniRef100_P81534
UniRef90:
UniRef90_P81534
UniRef50:
UniRef50_P81534
UniGene:
Hs.283082,
Hs.637221
CCDS:
CCDS43701.1,
CCDS34810.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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