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41273 hth

41273

hth

homothorax

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition homothorax

研究结论

Date Results Publications
2019-02-02 11:55:00 Rather than directly regulating cell cycle genes, hth and tsh control cell proliferation through an intermediary layer of nuclear receptors of the ecdysone/estrogen-signaling pathway. 28687780
2018-06-30 11:47:00 The Ubx cofactor, Homothorax (Hth), was co-enriched with Ubx near enhancers that require Hth, even though Ubx and Hth did not co-localize throughout the nucleus. Thus, microenvironments of high local transcription factor and cofactor concentrations could help low-affinity sites overcome their kinetic inefficiency. 29095143
2017-06-03 10:55:00 Hth+Tsh-induced tissue overgrowth requires the BMP2 Dpp and the abnormal hyperactivation of its pathway. Rather than using autocrine Dpp expression, Hth+Tsh cells increase their avidity for Dpp, produced locally, by upregulating extracellular matrix components. 27502436
2016-02-13 12:10:00 the satellite repeats get transcribed in wild type embryos and that this transcription depends on the presence of Hth, which binds to them as well as to the ribosomal DNA region. 25794008
2015-07-25 10:27:00 The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex 25790852

名称对应

Type IDs
Synonymous 1323/07, 1422/04, CG17117, Dm-HTH, Dmel\CG17117, HTH, Hth, MEIS1, Meis1, P53, anon-EST:Liang-2.13, clone 2.13, dtl, hth1, hth2, l(3)05745, l(3)86Ca
Gene
UniProtKB-ID: HTH_DROME, J7HAH8_DROME
UniprotKB: O46339, J7HAH8
UniParc: UPI0001750270, UPI0000083CD9, UPI000057C522, UPI00000847F7, UPI0001750272
EMBL: AE014297, BT024210, BT010238, AF026788, BT149862, AF032865, AF035825, AF036584, BT029117
EnsemblGenome: FBgn0001235
KO: dme:Dmel_CG17117
Nucleutide sequences
EMBL-CDS: AAZ52527.1, AAB88514.1, AAQ23556.1, AAB97169.1, ABJ17050.1, AAN13474.1, AAX52943.2, ABC86272.1, AAN13475.2, AAB88863.1, AAC47759.1, AAF54533.2, AFP95719.1
Gene_ORFName: CG17117
EnsemblGenome_TRS: FBtr0344145, FBtr0082255, FBtr0100455, FBtr0100454, FBtr0100454
Protein sequencees
EnsemblGenome_PRO: FBpp0099878, FBpp0099879, FBpp0081732, FBpp0310558, FBpp0099878
RefSeq: NP_001014613.2, NP_476577.3, NP_476576.1, NP_476578.3, NP_001027170.1
Others
UniRef100: UniRef100_J7HAH8, UniRef100_O46339
UniRef90: UniRef90_A0A0Q9X411, UniRef90_O46339
UniRef50: UniRef50_O46339-6, UniRef50_O46339
UniGene: Dm.2272

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