heg1 - heart development protein with EGF-like domains 1-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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406202 heg1

基因描述

Type	Description
Definition	heart development protein with EGF-like domains 1

研究结论

Date	Results	Publications
2018-09-01 12:06:00	In turn, Heg1 stabilizes levels of Krit1 protein, and both Heg1 and Krit1 dampen expression levels of klf2a, a major mechanosensitive gene. The correct balance of blood-flow-dependent induction and Krit1 protein-mediated repression of klf2a and notch1b ultimately shapes cardiac valve leaflet morphology.	29364115
2014-06-13 13:33:00	heart of glass encodes a previously uncharacterized endocardial signal that is vital for patterning concentric growth of the heart	14680629

名称对应

Type	IDs
Synonymous	heg
Gene	UniProtKB-ID: A9C3V5_DANRE UniprotKB: A9C3V5 UniParc: UPI00015A603C EMBL: BC162109, CR933561, BC162480 Ensembl: ENSDARG00000018441 KO: dre:406202
Nucleutide sequences	EMBL-CDS: AAI62109.1, AAI62480.1 Ensembl_TRS: ENSDART00000004462
Protein sequencees	Ensembl_PRO: ENSDARP00000012786 RefSeq: NP_998133.2
Others	UniRef100: UniRef100_A9C3V5 UniRef90: UniRef90_Q6R8J2 UniRef50: UniRef50_Q6R8J2 UniGene: Dr.29400

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
29364115	Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis. Elife Stefan Donat , Marta LourenÃ§o , Alessio Paolini , CÃ©cile Otten , Marc Renz , Salim Abdelilah-Seyfried	2018-02-01	-
28242613	Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart. Development Juliane MÃ¼nch , Dimitrios Grivas , Ãlvaro GonzÃ¡lez-Rajal , Rebeca Torregrosa-CarriÃ³n , JosÃ© Luis de la Pompa	2017-04-15	-
27189481	Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. BMC Genomics Jeremy Pasquier , CÃ©dric Cabau , Thaovi Nguyen , Elodie Jouanno , Dany Severac , Ingo Braasch , Laurent Journot , Pierre Pontarotti , Christophe Klopp , John H Postlethwait , Yann Guiguen , Julien Bobe	2016-05-18	-
26469318	RFX transcription factors are essential for hearing in mice. Nat Commun Ran Elkon , Beatrice Milon , Laura Morrison , Manan Shah , Sarath Vijayakumar , Manoj Racherla , Carmen C Leitch , Lorna Silipino , Shadan Hadi , MichÃ¨le Weiss-Gayet , EmmanuÃ¨le Barras , Christoph D Schmid , Aouatef Ait-Lounis , Ashley Barnes , Yang Song , David J Eisenman , Efrat Eliyahu , Gregory I Frolenkov , Scott E Strome , BÃ©nÃ©dicte Durand , Norann A Zaghloul , Sherri M Jones , Walter Reith , Ronna Hertzano	2015-10-15	-
24683187	Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. J. Immunol. ValÃ©rie Briolat , Luc Jouneau , Ralph Carvalho , Nuno Palha , Christelle Langevin , Philippe Herbomel , Olivier Schwartz , Herman P Spaink , Jean-Pierre Levraud , Pierre Boudinot	2014-05-01	si:dkey-225f5.5, g6pcb, ms4a17c.1, nfil3-4, unc93b1, gzm3, si:ch211-165b19.5, eif2ak2, si:ch211-165b19.8, si:ch211-165b19.9, ifit11, uba7, gbp4, irf4a, si:ch211-229n2.7, ms4a17a.17, ms4a17a.8, zmp:0000001138, ifitm1, cry1aa, map3k14a, mvb12bb, si:dkey-188i13.11, si:ch211-197g15.8, fn1a, ssbp3a, rin2, il6st, abtb2b, si:dkey-79f11.4, socs1b, si:dkey-79f11.10, si:dkey-79f11.7, si:dkey-79f11.5, ms4a17a.6, etv7, si:dkey-204f11.3, pnrc1, trafd1, zgc:162182, zgc:163136, crp7, zgc:171951, ms4a17a.4, ifnphi3, serpine1, abcb4, zgc:172295, cyp1c2, crp3, si:ch211-281g13.5, si:dkey-145c18.3, mhc1lfa, lgals9l6, si:dkeyp-9d4.2, si:ch211-71m22.3, dhx58, si:dkey-145c18.2, si:ch211-71m22.1, akt3b, si:dkey-166c18.1, si:dkey-79f11.9, cyp1b1, abca5, gak, cdkn1a, gch1, si:dkey-188i13.7, bub1, si:dkeyp-75b4.9, adm2b, nampta, tap1, si:ch211-231m23.4, vsig10l, usp18, slc16a1a, tlr7, si:ch211-122c9.5, slc25a28, si:ch211-241b2.5, znfx1, si:dkey-77f5.10, gpr37a, ms4a17c.2, si:ch211-234p6.5, cxcl11.6, cxcl11.7, tspan2b, epsti1, odc1, dusp5, blzf1, tnfrsfa, mafbb, mab21l2, her9, cebpd, scarb2
23897685	Zebrafish models of human liver development and disease. Compr Physiol Benjamin J Wilkins , Michael Pack	2013-07-01	vps18, mir122, met, mir30a, bcl2l1, sox32, hdac1, klf6a, rbp4, hhex, wnt2, mafba, fzd5, gata5, gata4, sox17, acvr1l, prox1a, top2a, fgf10a, prickle1a, rbm19, hdac3, heg1, uhrf1, snx7, vps33b, wnt2bb, snapc4, gata6, mcl1a, sox9b, cldn15b, grna, hnf1ba
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
19708646	Versatile synthesis and rational design of caged morpholinos. J. Am. Chem. Soc. Xiaohu Ouyang , Ilya A Shestopalov , Surajit Sinha , Genhua Zheng , Cameron L W Pitt , Wen-Hong Li , Andrew J Olson , James K Chen	2009-09-23	noto, tbx16, ta, heg1, etv2
19151727	Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med Benjamin Kleaveland , Xiangjian Zheng , Jian J Liu , Yannick Blum , Jennifer J Tung , Zhiying Zou , Shawn M Sweeney , Mei Chen , Lili Guo , Min-min Lu , Diane Zhou , Jan Kitajewski , Markus Affolter , Mark H Ginsberg , Mark L Kahn	2009-02-01	-
18206866	Development of the proepicardial organ in the zebrafish. Dev. Biol. Fabrizio C Serluca	2008-03-01	-

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