| Type | Description |
|---|---|
| Definition | Sp7 transcription factor |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 13:15:00 | cell transfection experiments demonstrated that Sp7 directly regulates the expression of dlx2b and bglap through Sp7-binding sites on the promoter regions of these two genes. Overall, this study provides new insight into the role of Sp7 in bone mineralization and tooth development. | 31894108 |
| 2018-04-07 12:01:00 | In zebrafish lacking sp7, attachment bone is never present, independent of the stage of tooth development or fish age, yet replacement is not interrupted. There was abnormal orientation of teeth, and abnormal connection of pulp cavities of predecessor and replacement teeth, arrested dentinogenesis, non-polarization of odontoblasts and only a thin layer of dentin deposition. | 29409769 |
| 2017-05-13 13:42:00 | Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth | 26992365 |
| 2016-06-28 11:26:00 | FGF and Wnt/beta-Catenin pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation. | 26689368 |
| 2011-02-05 10:50:00 | Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line. | 20506187 |
| Type | IDs |
|---|---|
| Synonymous | osterix, osx |
| Gene |
UniProtKB-ID:
Q6U1J4_DANRE
UniprotKB:
Q6U1J4
UniParc:
UPI00002307CB
EMBL:
AY380818
KO:
dre:405789
|
| Nucleutide sequences |
EMBL-CDS:
AAR28109.1
|
| Protein sequencees |
RefSeq:
NP_998028.1
|
| Others |
UniRef100:
UniRef100_Q6U1J4
UniRef90:
UniRef90_Q6U1J4
UniRef50:
UniRef50_Q8VI67
UniGene:
Dr.90855
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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