| Type | Description |
|---|---|
| Definition | endogenous retrovirus group FRD member 1, envelope |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 10:50:00 | There was a difference (p < 0.0001) between trisomy 7 and other patient groups and controls, regarding to the expression of syncytin-1 gene. Numerous mutations in the syncytin-1 and syncytin-2 genes (on the expression sites) were detected, and the mutation rate was higher in the syncytin-1 gene compared to the syncytin-2 gene in the patient and in the control groups (p < 0.001) | 32145327 |
| 2018-10-06 12:05:00 | genetic predisposition in ERVFRDE-1 may be associated with an increased risk of preeclampsia. This polymorphism is possibly involved in the regulation of syncytin-2 expression in preeclamptic placenta. | 29750965 |
| 2017-08-05 12:41:00 | N-glycans at residues 133, 312, 332 and 443 of syncytin-2 are required for optimal fusion induction, and that single-nucleotide polymorphism C46R, N118S, T367M, R417H, V483I and T522M can alter the fusogenic function of syncytin-2. | 26853155 |
| 2017-04-15 11:27:00 | Decreased syncytin-2 and MFSD2 proteins in gestational diabetic placentas might cause abnormal syncytiotrophoblast formation and possibly be involved in the pathology | 26875564 |
| 2017-01-14 11:57:00 | ERVWE1, ERVFRDE1 and ERV3 transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia. | 26992684 |
| Type | IDs |
|---|---|
| Synonymous | ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD |
| Gene |
UniProtKB-ID:
SYCY2_HUMAN
UniprotKB:
P60508
UniParc:
UPI00001C0961
EMBL:
AY358244,
AK123938,
BC068585,
AL136139
Ensembl:
ENSG00000244476
KO:
hsa:405754
|
| Nucleutide sequences |
EMBL-CDS:
AAQ88611.1,
AAH68585.1,
BAC85731.1
Gene_ORFName:
UNQ6191/PRO20218
Ensembl_TRS:
ENST00000472091,
ENST00000542862
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000420174,
ENSP00000444461
RefSeq:
NP_997465.1
|
| Others |
UniRef100:
UniRef100_P60508
UniRef90:
UniRef90_P60508
UniRef50:
UniRef50_P60508
UniGene:
Hs.631996
CCDS:
CCDS4519.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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