| Type | Description |
|---|---|
| Definition | serine peptidase inhibitor, Kazal type 6 |
| Date | Results | Publications |
|---|---|---|
| 2018-02-24 11:57:00 | Study showed that the expression of SPINK6 is specifically suppressed in liver tumor tissues. The suppression could be even detected in the early stage tumors. As SPINK6 is a secretory protein, the extracellular protein level may be decreased because of tumor development. These results support that SPINK6 is an important tumor suppressor in liver. | 27999203 |
| 2017-07-29 10:07:00 | our results identified a novel EGFR-activating mechanism in which SPINK6 has a critical role in promoting nasopharyngeal carcinoma metastasis | 27671677 |
| 2017-05-20 14:34:00 | a significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions | 27354280 |
| 2016-07-16 10:35:00 | KLKs. Thereby, beside the conserved binding mode, we identified an alternate binding mode which has so far not been observed for SPINK inhibitors. | 26828269 |
| 2014-06-21 10:53:00 | Our study indicates that Spink6 is a potent inhibitor of kallikrein related peptidases and involved in skin barrier function. | 24352040 |
| Type | IDs |
|---|---|
| Synonymous | BUSI2, UNQ844 |
| Gene |
UniProtKB-ID:
ISK6_HUMAN
UniprotKB:
Q6UWN8
UniParc:
UPI000004BA6C
EMBL:
GQ504704,
BC032003,
AY358716,
CH471062,
GQ504705
Ensembl:
ENSG00000178172
KO:
hsa:404203
|
| Nucleutide sequences |
EMBL-CDS:
ADM46526.1,
EAW61813.1,
AAQ89078.1,
ADM46527.1,
AAH32003.1
Gene_ORFName:
UNQ844/PRO1782
Ensembl_TRS:
ENST00000621437,
ENST00000325630
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000324870,
ENSP00000481309
RefSeq:
NP_001182219.1,
NP_995313.2
|
| Others |
UniRef100:
UniRef100_Q6UWN8
UniRef90:
UniRef90_Q6UWN8
UniRef50:
UniRef50_P01001
UniGene:
Hs.334274
CCDS:
CCDS34268.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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