| Type | Description |
|---|---|
| Definition | Sak kinase |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:30:00 | A molecular mechanism for the procentriole recruitment of Ana2. | 31841145 |
| 2019-09-14 11:09:00 | Nonphosphorylated Asl binds Plk4 and stimulates its kinase activity, but after Asl is phosphorylated, a negative-feedback mechanism suppresses Plk4 activity. This dual regulatory effect by Asl-A may limit Plk4 to bursts of activity that modulate centriole duplication. | 30256714 |
| 2018-09-08 10:33:00 | Plk4 phosphorylates Cep135 to properly position the essential centriole component Asterless. | 27558293 |
| 2018-07-21 10:54:00 | Plk4 phosphorylates Ana2 at S38 and STAN motif and promotes Ana2 recruitment to the centriole. | 29263250 |
| 2016-09-24 11:32:00 | When Asl reduction is attenuated by Asl overexpression, plk4 mutations, Plk4 or Slimb overexpression, Asl levels are higher in spermatozoa, resulting in embryos with reduced viability. | 26480844 |
| Type | IDs |
|---|---|
| Synonymous | CG7186, DmSAK, Dmel\CG7186, PLK4, Plk4, SAK/PLK, SAK/PLK4, Sak, Sak/PLK4, Sak/Plk4, plk4, sak |
| Gene |
UniProtKB-ID:
PLK4_DROME
UniprotKB:
O97143
UniParc:
UPI000007A62E
EMBL:
AF106952,
BT004846,
BT044561,
AE014296
EnsemblGenome:
FBgn0026371
KO:
dme:Dmel_CG7186
|
| Nucleutide sequences |
EMBL-CDS:
AAD19607.1,
AAF51737.1,
AAO45202.1,
ACI15756.1
Gene_ORFName:
CG7186
EnsemblGenome_TRS:
FBtr0078387
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0078042
RefSeq:
NP_649324.1
|
| Others |
UniRef100:
UniRef100_O97143
UniRef90:
UniRef90_O97143
UniRef50:
UniRef50_O97143
UniGene:
Dm.3240
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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