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403811 KIT

403811

KIT

KIT proto-oncogene receptor tyrosine kinase

protein-coding

Canis lupus familiaris

基因描述

Type Description
Definition KIT proto-oncogene receptor tyrosine kinase

研究结论

Date Results Publications
2020-06-13 12:25:00 C-kit is degraded after reovirus infection in canine mast cell tumor cell lines. 31345575
2019-06-08 11:59:00 mutations in these genes could serve as genetic markers for molecular stratification of cutaneous mast cell tumors and predictors of clinical outcome 30971355
2018-07-07 10:17:00 the pan deubiquitinating enzyme inhibitor PR619 prevented imatinib induction of KIT overexpression, suggesting that the imatinib-induced decrease in KIT ubiquitination could be mediated by upregulation and/or activation of deubiquitinating enzyme(s). It may be possible that a similar mechanism of KIT overexpression underlies the acquisition of imatinib resistance in some human tumors that are driven by KIT mutation. 28765927
2018-03-10 10:29:00 Tumors with KIT mutations showed genome-wide aberrant copy number profiles, with frequent CNAs (DNA copy number aberrations) involving genes in the p53 and RB pathways, whereas CNAs were very limited in tumors with wild-type KIT 28058543
2018-02-24 11:02:00 KTN0158 inhibits KIT phosphorylation, demonstrates an acceptable safety profile in dogs, and provides objective responses in canine MCT patients with and without activating KIT mutations, supporting future clinical evaluation of KTN0158 in people. 27815356

名称对应

Type IDs
Synonymous c-KIT
Gene
UniProtKB-ID: KIT_CANLF
UniprotKB: O97799
UniParc: UPI00001ABED8, UPI0000087ACB
EMBL: AY296484, AF044249, AF448148, AY313776
Ensembl: ENSCAFG00000002065
KO: cfa:403811
Nucleutide sequences
EMBL-CDS: AAL40833.1, AAD02327.1, AAP76390.1, AAP51178.1
Ensembl_TRS: ENSCAFT00000003274
Protein sequencees
Ensembl_PRO: ENSCAFP00000003042
RefSeq: XP_005628025.1, NP_001003181.1, XP_005628026.1, XP_005628027.1
Others
UniRef100: UniRef100_O97799
UniRef90: UniRef90_O97799
UniRef50: UniRef50_P10721
UniGene: Cfa.184

全选

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研究热度

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