| Type | Description |
|---|---|
| Definition | KIT proto-oncogene receptor tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 12:25:00 | C-kit is degraded after reovirus infection in canine mast cell tumor cell lines. | 31345575 |
| 2019-06-08 11:59:00 | mutations in these genes could serve as genetic markers for molecular stratification of cutaneous mast cell tumors and predictors of clinical outcome | 30971355 |
| 2018-07-07 10:17:00 | the pan deubiquitinating enzyme inhibitor PR619 prevented imatinib induction of KIT overexpression, suggesting that the imatinib-induced decrease in KIT ubiquitination could be mediated by upregulation and/or activation of deubiquitinating enzyme(s). It may be possible that a similar mechanism of KIT overexpression underlies the acquisition of imatinib resistance in some human tumors that are driven by KIT mutation. | 28765927 |
| 2018-03-10 10:29:00 | Tumors with KIT mutations showed genome-wide aberrant copy number profiles, with frequent CNAs (DNA copy number aberrations) involving genes in the p53 and RB pathways, whereas CNAs were very limited in tumors with wild-type KIT | 28058543 |
| 2018-02-24 11:02:00 | KTN0158 inhibits KIT phosphorylation, demonstrates an acceptable safety profile in dogs, and provides objective responses in canine MCT patients with and without activating KIT mutations, supporting future clinical evaluation of KTN0158 in people. | 27815356 |
| Type | IDs |
|---|---|
| Synonymous | c-KIT |
| Gene |
UniProtKB-ID:
KIT_CANLF
UniprotKB:
O97799
UniParc:
UPI00001ABED8,
UPI0000087ACB
EMBL:
AY296484,
AF044249,
AF448148,
AY313776
Ensembl:
ENSCAFG00000002065
KO:
cfa:403811
|
| Nucleutide sequences |
EMBL-CDS:
AAL40833.1,
AAD02327.1,
AAP76390.1,
AAP51178.1
Ensembl_TRS:
ENSCAFT00000003274
|
| Protein sequencees |
Ensembl_PRO:
ENSCAFP00000003042
RefSeq:
XP_005628025.1,
NP_001003181.1,
XP_005628026.1,
XP_005628027.1
|
| Others |
UniRef100:
UniRef100_O97799
UniRef90:
UniRef90_O97799
UniRef50:
UniRef50_P10721
UniGene:
Cfa.184
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| 1 |
College of Veterinary Medicine |
5 |
| 2 |
The University of Tokyo |
2 |
| 3 |
Freie Universität Berlin |
2 |
| 4 |
The Veterinary Cancer Center, Norwalk, Connecticut. |
1 |
| 5 |
The Ohio State University |
1 |
| 排名 | 研究人员 | 文献 |
|---|---|---|
| 1 |
Vilma Yuzbasiyan-Gurkan |
4 |
| 2 |
Matti Kiupel |
3 |
| 3 |
Joshua D Webster |
2 |
| 4 |
Makoto Bonkobara |
2 |
| 5 |
M Kiupel |
2 |