| Type | Description |
|---|---|
| Definition | ADP ribosylation factor like GTPase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 12:13:00 | Low ARL3 expression predicted poor prognosis and contributed to antiangiogenesis and the proportion of infiltrating immune cells in the GBM microenvironment. Thus, ARL3 may be a prognostic marker and therapeutic target for glioma. | 31234870 |
| 2020-03-14 11:30:00 | Our study confirms that the ARL3 missense variant p.(Tyr90Cys) causes retinitis pigmentosa. | 30932721 |
| 2020-02-01 12:50:00 | Our study uncovers an additional cone rod dystrophy (CRD) gene and assigns the CRD phenotype to a variant of ARL3. The results imply that cargo transportation in photoreceptors as mediated by the ARL3 pathway is essential for cone and rod cell survival and vision in humans. | 31743939 |
| 2019-09-07 10:49:00 | We utilized a structure-based approach to pinpoint the binding interface to a strictly conserved cluster of residues on the surface of RP2 that spans both the C- and N-terminal domains of the protein, and which is structurally distinct from the ARL3-binding site.RP2 is a positive regulator of cell motility in vitro, recruiting OSTF1 to the cell membrane and preventing its interaction with the migration regulator Myo1E. | 29361551 |
| 2019-05-18 10:57:00 | ARL3 provides a potential hub in the network of proteins implicated in ciliopathies. | 30269812 |
| Type | IDs |
|---|---|
| Synonymous | ARFL3, JBTS35, RP83 |
| Gene |
UniProtKB-ID:
ARL3_HUMAN
UniprotKB:
P36405
UniParc:
UPI0000125EE4
EMBL:
BC009841,
AF493889,
U07151,
CR407637,
AK312525,
AL391121
Ensembl:
ENSG00000138175
KO:
hsa:403
|
| Nucleutide sequences |
EMBL-CDS:
BAG35424.1,
AAH09841.1,
AAA21654.1,
CAG28565.1,
AAM12603.1
Ensembl_TRS:
ENST00000260746
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260746
RefSeq:
NP_004302.1,
XP_016871749.1
|
| Others |
UniRef100:
UniRef100_P36405
UniRef90:
UniRef90_P36405
UniRef50:
UniRef50_P36405
UniGene:
Hs.182215
CCDS:
CCDS7538.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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