psenen - presenilin enhancer, gamma-secretase subunit-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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402810 psenen

基因描述

Type	Description
Definition	presenilin enhancer, gamma-secretase subunit

研究结论

Date	Results	Publications
2016-04-30 10:55:00	Both human PS2V and zebrafish PS1IV can stimulate gamma-secretase activity despite extreme structural divergence.	25814654

名称对应

Type	IDs
Synonymous	pen-2, pen2, zgc:109727
Gene	UniProtKB-ID: PEN2_DANRE UniprotKB: Q8JHF0 UniParc: UPI00000FBA7E EMBL: BC092674, AF512427 Ensembl: ENSDARG00000068698 KO: dre:402810
Nucleutide sequences	EMBL-CDS: AAH92674.1, AAM88324.1 Gene_ORFName: zgc:109727 Ensembl_TRS: ENSDART00000099456, ENSDART00000186625
Protein sequencees	Ensembl_PRO: ENSDARP00000090230, ENSDARP00000153835 RefSeq: NP_991139.1
Others	UniRef100: UniRef100_Q8JHF0 UniRef90: UniRef90_Q8JHF0 UniRef50: UniRef50_Q86BE9 UniGene: Dr.151555

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
28287404	Mutations in Î³-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa. J. Clin. Invest. Damian J Ralser , F Buket Ã Basmanav , Aylar Tafazzoli , Jade Wititsuwannakul , Sarah Delker , Sumita Danda , Holger Thiele , Sabrina Wolf , MichÃ©lle Busch , Susanne A Pulimood , Janine AltmÃ¼ller , Peter NÃ¼rnberg , Didier Lacombe , Uwe Hillen , JÃ¶rg Wenzel , Jorge Frank , Benjamin Odermatt , Regina C Betz	2017-04-03	-
26469318	RFX transcription factors are essential for hearing in mice. Nat Commun Ran Elkon , Beatrice Milon , Laura Morrison , Manan Shah , Sarath Vijayakumar , Manoj Racherla , Carmen C Leitch , Lorna Silipino , Shadan Hadi , MichÃ¨le Weiss-Gayet , EmmanuÃ¨le Barras , Christoph D Schmid , Aouatef Ait-Lounis , Ashley Barnes , Yang Song , David J Eisenman , Efrat Eliyahu , Gregory I Frolenkov , Scott E Strome , BÃ©nÃ©dicte Durand , Norann A Zaghloul , Sherri M Jones , Walter Reith , Ronna Hertzano	2015-10-15	-
25814654	Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of Î³-secretase activity. Hum. Mol. Genet. Seyyed Hani Moussavi Nik , Morgan Newman , Lachlan Wilson , Esmaeil Ebrahimie , Simon Wells , Ian Musgrave , Giuseppe Verdile , Ralph N Martins , Michael Lardelli	2015-07-01	-
23794287	Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation. Mol. Neurobiol. Ying-Tsen Tung , Bo-Jeng Wang , Wen-Ming Hsu , Ming-Kuan Hu , Guor Mour Her , Wei-Pang Huang , Yung-Feng Liao	2014-02-01	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
16364449	Computerized image analysis for quantitative neuronal phenotyping in zebrafish. J. Neurosci. Methods Tianming Liu , Jianfeng Lu , Ye Wang , William A Campbell , Ling Huang , Jinmin Zhu , Weiming Xia , Stephen T C Wong	2006-06-15	psen1, her6, tp53, aph1b, psenen, psen2
16507571	The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis. J Biol Chem Henrik Zetterberg , William A Campbell , Hong Wei Yang , Weiming Xia	2006-04-28	-
16464238	Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J. Neurochem. William A Campbell , Hongwei Yang , Henrik Zetterberg , StÃ©phanie Baulac , Jacqueline A Sears , Tianming Liu , Stephen T C Wong , Tao P Zhong , Weiming Xia	2006-03-01	-
12477932	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team	2002-12-24	-
12110170	aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell Ross Francis , Garth McGrath , Jianhuan Zhang , David A Ruddy , Mary Sym , Javier Apfeld , Monique Nicoll , Mark Maxwell , Bing Hai , Michael C Ellis , Annette L Parks , Wei Xu , Jinhe Li , Mark Gurney , Richard L Myers , Carol S Himes , Ronald Hiebsch , Cara Ruble , Jeffrey S Nye , Daniel Curtis	2002-07-01	-

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