| Type | Description |
|---|---|
| Definition | karyopherin subunit alpha 7 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:26:00 | An epilepsy-associated mutation in the nuclear import receptor reduces nuclear localization signal binding. | 32179771 |
| 2020-07-11 11:51:00 | an isoform with expression mostly limited to early development, can bind Importin-beta (Imp-beta) in the absence of NLS cargo. | 31642884 |
| 2018-12-22 12:33:00 | has a critical role in the regulation of mitosis through the proper organization of the mitotic spindle and acts in the maintenance of the nuclear envelope structure and nuclear morphology. | 29580221 |
| 2018-12-22 11:12:00 | binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth. | 27664836 |
| 2015-01-31 11:14:00 | Our data show that compound heterozygous mutations in are associated with a human neurodevelopmental disease, and provide the first example of a human disease associated with mutation of a nuclear transport receptor. | 24045845 |
| Type | IDs |
|---|---|
| Synonymous | IPOA8 |
| Gene |
UniProtKB-ID:
IMA8_HUMAN
UniprotKB:
A9QM74
UniParc:
UPI00004193B5
EMBL:
EU126604,
CH236956
Ensembl:
ENSG00000284068,
ENSG00000185467
KO:
hsa:402569
|
| Nucleutide sequences |
EMBL-CDS:
ABW96272.1,
EAL23884.1
Ensembl_TRS:
ENST00000327442,
ENST00000640158
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000330878,
ENSP00000491331
RefSeq:
XP_016867698.1,
XP_016867704.1,
NP_001139187.1,
XP_016867699.1,
XP_016867703.1,
XP_016867701.1,
XP_016867702.1,
XP_016867697.1,
XP_016867705.1,
XP_016867700.1,
XP_011514517.1
|
| Others |
UniRef100:
UniRef100_A9QM74
UniRef90:
UniRef90_A9QM74
UniRef50:
UniRef50_A9QM74
UniGene:
Hs.253050
CCDS:
CCDS47651.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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