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40133 ash1

40133

ash1

absent, small, or homeotic discs 1

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition absent, small, or homeotic discs 1

研究结论

Date Results Publications
2020-04-18 11:10:00 Trx, Ash1, and CBP proteins are required for the correct chromosome segregation and that Ash1 and CBP mediate for Cid/CENP-A recruitment at centromeres through post-translational histone modifications. Centromeric H3 histone is consistently acetylated in K27 by CBP and that nej and ash1 silencing respectively causes a decrease in H3K27 acetylation and H3K4 methylation along with an impairment of Cid loading. 31203392
2018-10-06 11:37:00 Mrg15 is a subunit of the Ash1 complex, a stimulator of Ash1 enzymatic activity and a critical regulator of the TrxG protein function of Ash1 in Drosophila. 29158494
2018-05-26 10:06:00 Ash1 HMTase activity is activated by MRG15, a subunit of the identified Ash1 complex, and that this complex, rather than the Ash1 protein alone, is the active form of this H3K36 methyltransferase, both in vitro and in vivo. 29540501
2017-04-08 12:02:00 If ASH1 or TRX function is lost or reduced, heterochromatin can spread into these domains creating a sink that diverts heterochromatic proteins from other variegating locations, which then may express a suppressed phenotype. 27373142
2015-04-04 10:17:00 Physical interaction of ASH1 with FSH activates global transcription. 23442797

名称对应

Type IDs
Synonymous ASH-1, ASH1, Ash, Ash 1, Ash1, CG8887, Dmel\CG8887, ash, ash-1, dash, l(3)76BDb, l(3)SG29a
Gene
UniProtKB-ID: ASH1_DROME
UniprotKB: Q9VW15
UniParc: UPI0000E5704E
EMBL: U49439, BT031135, AY122246, AE014296
EnsemblGenome: FBgn0005386
KO: dme:Dmel_CG8887
Nucleutide sequences
EMBL-CDS: AAB01100.1, AFH04505.1, AAF49140.3, ABX00757.1, AAM52758.1
Gene_ORFName: CG8887
EnsemblGenome_TRS: FBtr0306009, FBtr0306010
Protein sequencees
EnsemblGenome_PRO: FBpp0297151, FBpp0297152
RefSeq: NP_001246834.1, NP_524160.2
Others
UniRef100: UniRef100_Q9VW15
UniRef90: UniRef90_Q9VW15
UniRef50: UniRef50_Q9VW15
UniGene: Dm.7698

全选

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