| Type | Description |
|---|---|
| Definition | LIM domain only 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:32:00 | FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK. | 32910224 |
| 2020-06-20 10:20:00 | our data suggest that Zeb2 and Lmo2 drive malignant transformation of immature T-cell progenitors via distinct molecular mechanisms. | 30679322 |
| 2020-05-23 12:34:00 | Study demonstrates that in diffuse large B cell lymphomas LMO2 controls DNA double-strand break (DSB) pathway choice, resulting in homologous recombination dysfunction and tumor cell sensitization to genotoxic agents that could be further enhanced with inhibitors. Mechanistically, LMO2 inhibits BRCA1 recruitment to DSBs by interacting with 53BP1 during repair. | 31447348 |
| 2020-05-16 10:14:00 | Study presents genetic evidence that the development of Wilms tumors in WAGR syndrome patients should be attributed to the deletion of WT1 and LMO2 rather than WT1 only. | 31304537 |
| 2020-02-01 10:38:00 | Lysine deacetylation of LMO2 is essential for the LDB1 interaction and transcriptional activity of the TAL1 complex. | 31366618 |
| Type | IDs |
|---|---|
| Synonymous | LMO-2, RBTN2, RBTNL1, RHOM2, TTG2 |
| Gene |
UniProtKB-ID:
RBTN2_HUMAN
UniprotKB:
P25791
UniParc:
UPI00001F9F84,
UPI0000000F36,
UPI000198C54D
EMBL:
BC035607,
X61118,
BC073973,
BC034041,
BC042426,
AF257211
Ensembl:
ENSG00000135363
KO:
hsa:4005
|
| Nucleutide sequences |
EMBL-CDS:
AAH34041.1,
AAH42426.1,
AAH35607.1,
CAA43430.1,
AAH73973.1,
AAF98804.1
Ensembl_TRS:
ENST00000257818,
ENST00000395833,
ENST00000411482
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000379175,
ENSP00000401967,
ENSP00000257818
RefSeq:
XP_016873219.1,
XP_016873220.1,
XP_016873221.1,
XP_016873217.1,
NP_005565.2,
XP_016873218.1,
XP_005252978.1,
XP_016873222.1,
XP_016873216.1,
NP_001135788.1,
NP_001135787.1
|
| Others |
UniRef100:
UniRef100_P25791
UniRef90:
UniRef90_P25791
UniRef50:
UniRef50_P25791
UniGene:
Hs.34560
CCDS:
CCDS44567.1,
CCDS7888.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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