| Type | Description |
|---|---|
| Definition | acid sensing ion channel subunit 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:04:00 | Analysis of human autoptic brain tissue in multiple sclerosis (MS) and control samples showed an increase of ASIC 2 mRNA in MS samples. | 30549327 |
| 2020-02-08 10:45:00 | ASIC2 could be crucial in the pathogenesis of osteoporosis and could serve as a therapeutic target for antiosteoporotic therapies. | 31531354 |
| 2019-02-09 12:00:00 | hippocampal glucose hypometabolism elevates ASIC2a expression by suppressing TFCP2 expression, which further enhances the intrinsic excitability of CA1 pyramidal neurons and increases seizure susceptibility in patients with temporal lobe epilepsy. | 28725010 |
| 2018-07-14 11:29:00 | Study shows that ASIC2 promotes metastasis of colorectal cancer (CRC) cells by activating the calcineurin/NFAT1 pathway under acidosis and high expression of ASIC2 predicts poor outcomes of patients with CRC. | 28927426 |
| 2018-05-05 10:52:00 | The authors finally confirmed that the ASIC2b isoform is delivered to the cell surface from the endoplasmic reticulum by forming heteromers with ASIC2a isoform, and that the N-terminal region of ASIC2a is additionally required for the ASIC2a-dependent membrane targeting of ASIC2b. | 27477936 |
| Type | IDs |
|---|---|
| Synonymous | ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1 |
| Gene |
UniProtKB-ID:
ASIC2_HUMAN
UniprotKB:
Q16515
UniParc:
UPI00000441F0,
UPI000013C881
EMBL:
BC075042,
U50352,
AC123769,
AC011824,
AC078907,
AC004147,
AC015751,
AC024610,
U57352,
U53212,
AC005549,
AL834182,
AC025898,
AC003687,
AC008133,
AC027233,
BC075043,
AC024614
Ensembl:
ENSG00000108684
KO:
hsa:40
|
| Nucleutide sequences |
EMBL-CDS:
CAD38879.1,
AAH75042.1,
AAH75043.1,
AAC50432.1,
AAC50498.1,
AAB49182.1
Ensembl_TRS:
ENST00000359872,
ENST00000225823
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000352934,
ENSP00000225823
RefSeq:
NP_001085.2,
NP_899233.1
|
| Others |
UniRef100:
UniRef100_Q16515
UniRef90:
UniRef90_Q62962
UniRef50:
UniRef50_Q62962
UniGene:
Hs.368417
CCDS:
CCDS11276.1,
CCDS42296.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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